聪灵胶囊对实验性血小板性血栓形成抑制作用的初步研究

PRELIMZNARY STUDY OF DEPRESSANT EFFECT OF CONGLING CAPSULE ON PLATELET THROMBOSIS

目的:探讨聪灵胶囊抑制血小板凝集、抗血栓形成的作用。方法:建立动-静脉旁路血栓形成模型,喜得镇作为阳性对照药,研究聪灵胶囊对大鼠血栓形成的影响。结果:聪灵胶囊高中剂量组及阳性对照组的血栓湿重均明显降低,与空白对照组相比,具有显著性差异(P<0.05),聪灵胶囊高中剂量组与阳性对照组相比无显著性差异(P>0.05)。结论:聪灵胶囊具有一定程度的抑制血小板凝集、抗血栓形成的作用。

Objective： To study the inhibition of platelet aggregation and thrombosis by Congling Capsule. Methods：Thrombosis model was produced by putting a silk filament into plastic tube then inserting it between right common carotid artery and left external jugular vein, with hydergine as control. Wet weight of thrombus was measured .Results： Compared with the non-treatment group,the wet weight of thrombus in hydergine treatment group and high and medium dosage Congling Capsule groups was significanly declined （P〈0.05）.There was no significant difference between high or medium dosage Congling group （P〉0.05）.Conclusion： Congling Capsule is an effective aggregation and thrombosis. Key words Congling Capsule; Thrombosis Capsule treatment group and hydergine treatment Chinese herbal preparation for inhibition of platelet aggregation and thrombosis.