胎儿生长受限与正常妊娠孕妇血清皮质醇浓度、APOAI/APOB变化的研究

Study of relationship between serum cortisol concentration and the change of ApoAI/ApoB in pregnant women with fetal grown restriction and normotensive pregnant women

目的:探讨正常妊娠和胎儿生长受限孕妇血清皮质醇浓度和ApoAI/ApoB的变化,以及这些改变与胎儿生长受限发病的关系。方法:采用放射免疫法及免疫透射比浊法,测定50例胎儿生长受限孕妇、294例正常妊娠孕妇、56例非妊娠妇女(对照组)的血清皮质醇浓度、载脂蛋白ApoAI、AgpoB和ApoAI/ApoB比值。结果:正常妊娠孕妇血清皮质醇浓度、ApoAI和ApoB含量随着孕周增长而升高,较对照组有显著差异性(P<0.01),ApoAI/ApoB比值随着孕周增长略有上升(P>0.05)。与正常妊娠组比较,胎儿生长受限组皮质醇浓度显著升高(P<0.01),ApoAI/ApoB明显下降(P<0.01)。结论:测定孕妇血清皮质醇浓度、ApoAI/ApoB比值可作为孕期早期诊断胎儿生长受限的指标。

Objective： To investigate the serum cortisol concentration and the change of ApoAI/ApoB in pregnant women with fetal grown restriction （FGR）, normotensive pregnant women and non-pregnant women. Methods：50 women with FGR, 294 normotensive pregnant women and 56 non -pregnant ones were studied, from whom maternal blood samples were collected. The serum cortisol concentration were determined by radioimmtmoassay （RIA） and ApoAI and ApoB levels by radial immtmodiffusion. Results： Following pregnancy progress, the serum cortisol concentration and the levels of ApoAI and ApoB were higher in normotensive pregnant women than those in non-pregnant ones （P〈0.01）, and the change of ApoAI/ApoB tended to ascend （P〉 0.05）. The serum cortisol concentration were higher in pregnant women with FGR than that in normotensive pregnant ones （P〈0.01）, the change of ApoAI/ApoB tended to descend （P〈0.01）. Conclusion： The serum eortisol concentration and the change of ApoAI/ApoB may be potential markers for FGR diagnosis.