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WNK激酶在肾脏离子转运中的作用 被引量：2

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作者 吕晶玉 张墨 赵彦艳
机构地区 中国医科大学医学遗传学教研室 中国医科大学
出处 《中华高血压杂志》 CAS CSCD 北大核心 2007年第5期361-363,共3页 Chinese Journal of Hypertension
基金 国家自然科学基金项目(30500293) 教育部留学回国人员科研启动基金(2005-383)
关键词 离子转运 肾脏 WNK 激酶 LANCET 成人人群 高血压 危险因素
分类号 R544.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献24

  • 1[1]Kearney PM,Whelton M,Reynold K,et al.Global burden of hypertension:analysis of worldwide data[J].Lancet,2005,365:217-223.
  • 2[3]Xu B,English JM,Wilsbacher JL,et al.WNK1,a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomainⅡ[J].J Biol Chem,2000,275:16795-16801.
  • 3[4]Knighton DR,Zheng J,Ten Eyck LF,et al.Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate dependent protein kinase[J].Science,1991,253:414-429.
  • 4[5]Therrien M,Chang HC,Solomon NM,et al.KSR,a novel protein kinase required for RAS signal transduction[J].Cell,1995,83:879-888.
  • 5[6]Urakami-Kojima M,Nakamichi N,Yamashino T,et al.The APRR3 component of the clock-associated APRR1/TOC1 quintet is phosphorylated by a novel protein kinase belonging to the WNK family,the gene for which is also transcribed rhythmically in Arabidopsis Thaliana[J].Plant Cell Physiol,2002,43:675-683.
  • 6[7]Gordon,RD,Geddes RA,Pawsey CGK,et al.Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction[J].Aust Ann Med,1970,4:287-294.
  • 7[8]Mansfield TA,Simon,DB,Farfel Z,et al.Multilocus linkage of familial hyperkalaemia and hypertension,pseudohypoaldosteronism type Ⅱ,to chromosomes 1q31-42 and 17p11-q21[J].Nature Genet,1997,16:202-205.
  • 8[9]Wilson FH,Disse-Nicodeme S,Choate KA,et al.Human hypertension caused by mutations in WNK kinases[J].Science,2001,293:1107-1112.
  • 9[10]Monti J,Zimdahl H,Schulz H,et al.The role of WNK4 in polygenic hypertension:a candidate gene analysis on rat chromosome 10[J].Hypertension,2003,41:938-942.
  • 10[11]Wilson FH,Kahle KT,Sabath E,et al.Molecular pathogenesis of inherited hypertension with hyperkalemia:the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4[J].Proc Natl Acad Sci U S A,2003,100:680-684.

同被引文献47

  • 1郑杰.结直肠息肉和结直肠癌[J].中华病理学杂志,2005,34(1):4-5. 被引量：65
  • 2马莲环,刘建.ERK1/2的研究进展[J].国外医学（生理病理科学与临床分册）,2005,25(3):279-282. 被引量：21
  • 3Hong C,Moorefield KS,Jun P. Epigenome scans and cancer genome sequencing converge on WNK2,a kinase-independent suppressor of cell growth[J].Proceedings of the National Academy of Sciences(USA),2007,(26):10974-10979.doi:10.1073/pnas.0700683104.
  • 4Wheeler AP,Ridley AJ. Why three Rho Proteins? RhoA,RhoB,RhoC,and cell motility[J].Experimental Cell Research,2004,(01):43-49.
  • 5Moniz S,Matos P,Jordan P. WNK2 modulates MEK1 activi-ty through the Rho GTPase pathway[J].Cellular Signalling,2008,(10):1762-1768.doi:10.1016/j.cellsig.2008.06.002.
  • 6Moniz,Veríssimo F,Matos P. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2[J].Oncogene,2007,(41):6070-6081.
  • 7Chambard JC,LeflochR,Pouysségur J. ERK implication in cell cycle regulation[J].Biochimica Et Biophysica Acta,2007,(08):1299-1310.
  • 8Wilson FH, Disse-Nicodbme S, Choate KA. et al. Human hyper tension caused by mutations in WNK kinases[J]. Science, 2001, 293(5532) : 1107-1112.
  • 9Hoorn EJ, NelsonJH, McCormickJA, et al. The WNK kinase nelwork regulating sodium, potassium, and blood prcssure[J] JASN,2011,22(4):605-614.
  • 10Kahle KT, Wilson FH, I,eng Q, et al. WNK4 regulates the hal ance between renal NaCI reabsorption and K- secretion[J]. Nat Genet,2003,35(4) :372-376.

引证文献2

二级引证文献3

中华高血压杂志
2007年 第5期

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