阿托伐他汀对男性高血压患者勃起功能障碍的影响

The Effect of Atorvastatin on the Male Hypertensive Patients with Erectile Dysfunction

目的探讨阿托伐他汀对男性高血压患者勃起功能障碍(ED)的影响。方法入选我院2003-07-2006-06收治的男性轻中度高血压病人838例,随机分为两组:常规降压(对照组,n=374)和常规降压+阿托伐他汀(治疗组,n=369)。两组均先给予硝苯地平缓释片+依那普利进行常规降压治疗,如血压不能达标,加用氢氯噻嗪12.5mg/d。降压达标后治疗组加用阿托伐他汀10mg/d,对照组治疗方案不变。每4周随访1次,总共随访36周,调查分析治疗前后ED患病情况。结果治疗组有369例,对照组有374例完成随访,治疗前两组的ED患病率为60.2%vs60.9%(P>0.05),差异无统计学意义。治疗后加用阿托伐他汀组的ED患病率为46.3%vs对照组63.7%(P<0.01),差异有非常显著意义。结论阿托伐他汀可改善男性高血压患者勃起功能障碍。

Objective To investigate the effect of atorvastatin on the male hypertensive patients with erectile dysfunction（ED）. Methods Eight hundred and thirty-eight male patients with mild or moderate hypertension were randomly to receive routine antihypertensive group （control group, n= 374） or routine antihypertensive＋ atorvastatin group （therapy group, n=369）. The patients of both groups were given extended release nifedipine and enalapril to lower blood pressure; if blood pressure didn＇t reach the goal level, hydrochlorothiazide 12.5 mg/d were added. After blood pressure reached the goal level, atorvastatin 10 mg/d was added in therapy groups for 36 weeks. Results Before the treatment the morbidity rate of ED in the two groups was 60.9 % vs 60. 2 % （P〉 0. 05）. After treatment the incidence of ED in therapy group was decreased to 46.3% vs control group of 63.7% （P〈0.01）. Conclusion Atorvastatin may improve ED of the male patients with hypertension.