摘要
研究了异噻唑啉酮的关键中间体N,N′-二甲基-3,3′-二硫代二丙酰胺的合成。以丙烯酸甲酯为基础原料,经亲核加成、脱硫精制及酰胺化反应制得目的产物,总收率可达85%。同时详细讨论了反应物配比、反应温度及时间等因素对收率的影响。
The key intermediate N, N'-dimethyl-3,3'-dithodipropionamide for preparing isothiazolone was synthesized starting from methyl acrylate by nucleophilic addition,purification with desulfurization and amidating, the total yield reached 85%. The effects of reaction agent relative ratio,reaction temperature and reaction time on the yield were discussed
出处
《染料与染色》
CAS
2007年第2期31-33,24,共4页
Dyestuffs and Coloration
基金
宁波市青年(博士)基金(2005A60024)资助项目