致命鹅膏菌毒素对DMBA/巴豆油诱导小鼠皮肤肿瘤的治疗作用

The effects of Amanita exitialis toxin on the cure of mouse skin papillomas chemically induced by DMBA/croton oil

研究了致命鹅膏中的毒素在安全剂量下抑制小鼠皮肤肿瘤的效果,并对此毒素的药用安全性进行初步评价。采用经典的DMBA/巴豆油诱导小鼠皮肤乳头状瘤形成的二阶段致癌模型,观察和评价致命鹅膏毒素在不同剂量下抑制肿瘤的效果,并且通过测定血清中氨基己糖的含量来判断对肝损伤的情况。结果表明,致命鹅膏毒素在某一低剂量下对DMBA/巴豆油诱导小鼠皮肤乳头状瘤有较好的治愈效果,且对小鼠肝脏无损伤,证明了致命鹅膏毒素可以较好地治疗皮肤癌。

Inhibition effect of the toxin in Amanita exitialis on mouse skin papillomas under safe dose and the drug safety was evaluated primarily. The mouse skin papilloma model was established by 7,12-dimethylbenz （a） anthraene （DMBA） / croton oil induction, which was a classical two-stage cancer model. The inhibition effect of Amanita exitialis toxin was observed and evaluated under different doses. By means of analysis of amino-hexose in serum, the hepatic cell damage induced by toxin was determined. The result showed that Amanita exitialis toxin in low dose can cure skin tumor in dose-dependent manner, and no harmful effect for hepatic cell. It was concluded that Amanita exitialis toxin can cure skin cancer.