1667株临床分离菌株的耐药性分析

Analysis of Drug Tolerance on 1667 Clinically Isolated Bacteria Strains

目的了解2000年3月～2004年12月我院常见菌的耐药情况。方法收集临床及门诊送检细菌培养标本，进行细菌培养和耐药性分析。结果我院2000年3月～2004年12月送检的标本共分离菌株1667株，其中革兰阳性球菌671株，以金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌、腐生葡萄球菌、粪肠球菌为主；革兰阴性肠杆菌559株，以大肠埃希氏菌、肺炎克雷伯菌、肠杆菌为主；革兰阴性非发酵菌437株，以铜绿假单胞菌、洛菲不动杆菌为主。所分离的菌株对大多数抗生素耐药性有逐年增加趋势。结论了解抗生素的敏感性和耐药率变化有助于临床医生合理应用抗生素，制定正确的抗感染方案。

Objective To investigate the drug tolerance of common bacteria in our hospital from March 2000 to December 2004. Methods Collecting the specimens submitted by clinic and out-patient department, conducting bacteria culture and analyzing the drug tolerance. Results 1667 strains have been isolated from all specimens submitted in our hospital from March 2000 to December 2004, among which there are 671 strains of Gram-positive cocci： staphaureus, staphepidermidis, staphhaemolyticus, staphsaparophytics, E. faecalis and there are 559 strains of Gram-negative Enterobacteriaceae：E. coli, K. pneumoniae, Enterobacter and finally there are 437 strains of Gram-negative nonfermenters： P. aeruginosa, A. Iwoffi. The trend of drug tolerance for the isolated strains to most antibiotics has been going up year by year. Conclusion It＇s helpful for clinicians to investigate the changes of sensitivity and drug tolerance of antibiotics with a sound usage and then to make a proper plan for anti-infection.