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调节骨吸收相关基因的研究进展

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摘要 骨吸收是维持骨重建动态平衡过程的重要环节,受到许多基因的共同调控,研究调节骨吸收的相关基因及其作用,将为骨质疏松、骨缺损修复等治疗提供更先进、更肯定的手段和方式。调节骨吸收的相关基因主要有分泌性磷蛋白,肿瘤坏死因子11,血管内皮生长因子,胰岛淀粉样多肽,5磷酸肌醇,离子通道7型P2x受体,肿瘤坏死因子受体11b等。一些以基因组为背景,能够在整体水平上研究基因相互作用的新技术不断产生,对骨吸收相关基因的研究也将不断的深入和完善,为骨发育机制的研究、骨疾病的治疗奠定基础。
作者 胡飞 周磊
出处 《国际医药卫生导报》 2007年第9期4-7,共4页 International Medicine and Health Guidance News
基金 广东省医学科学技术研究基金(编号:A2005114)
关键词 骨吸收 基因 调节
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参考文献19

  • 1Helfrich MH,Nesbitt SA,Dorey EL,et al.Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins,including the bone sialoproteins and fibronectin,via a beta 3 integrin[J].Bone Miner Res,1992,7(3):335-343
  • 2Ek-Rylander B,Flores M,Wendel M,et al.Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase.Modulation of osteoclast adhesion in vitro[J].Biol Chem,1994,269(21):14853-14856
  • 3Katayama Y,House CM,Udagawa N,et al.Casein kinase 2 phosphorylation of recombinant rat osteopontin enhances adhesion of osteoclasts but not osteoblasts[J].Cell Physiol,1998,176(1):179-187
  • 4Razzouk S,Brunn JC,Qin C.Osteopontin posttranslational modifications,possibly phosphorylation,are required for in vitro bone resorption but not osteoclast adhesion[J].Bone,2002,30(1):40-47
  • 5Xu J,Tan JW,Huang L.Cloning,sequencing,and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand[J].Bone Miner Res,2000,15(11):2178-2186
  • 6Takahashi N,Udagawa N,Suda T.A new member of tumor necrosis factor ligand family,ODF/OPGL/TRANCE/RANKL,regulates osteoclast differentiation and function[J].Biochem Biophys Res Commun,1999,24,256(3):449-455
  • 7Komine M,Kukita A,Kukita T.Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal celldepleted rat bone marrow cell culture[J].Bone,2001,28(5):474-483
  • 8Yao Z,Lafage-Proust MH,Plouet J.Increase of both angiogenesis and bone mass in response to exercise depends on VEGF[J].Bone Miner Res,2004,19(9):1471-1480
  • 9Dacquin R,Davey RA,Laplace C.Amylin inhibits bone resorption while the calcitonin receptor contrels bone formation in vivo[J].Cell Biol,2004,16,164(4):509-514
  • 10Lerner UH.Deletions of genes encoding calcitonin/alpha-CGRP,amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone[J].Musculoskelet Neuronal Interact,2006,6(1):87-95

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