褐黄病

Ochronosis:a case report

报告1例褐黄病。患者男,49岁。面部、耳郭、双手背肤色呈蓝绿色20余年,排尿后尿液变黑40余年。皮损组织病理检查:表皮轻度萎缩、变薄,真皮内胶原纤维变性,胶原束肿胀,束间可见棕黄色、均质团块状物质沉积。甲苯胺蓝染色示团块状物质呈黑色。尿液加入10%NaOH溶液后变成黑色。腰椎X线检查示腰椎骨质疏松,椎间盘钙化,椎间盘突出。依据临床表现、组织病理检查及其他实验室检查结果诊断为褐黄病。

This case report described a 49-year-old man with alkaptonuric ochronosis who presented with black urine for forty years and the green-blue rash on the face, ears, dorsum of hands for twenty years. Histopathology showed yellow-brown deposition in boluses between collagen, which were darkened when staining with toluene blue. The urine＇ became black after adding 10%NaOH solution. Skeletal surveys presented osteoporosis of lumber vertebra, calcification and extrusion of intervertebral discs.