肾病综合征与慢性肾小球肾炎患者血脂、载脂蛋白及脂蛋白(a)水平的比较

Compare the level of blood fat, apolipoprotein and lipoprotein(a) between chronic glomerulonephritis and nephrotic syndrome

目的:研究慢性肾小球肾炎与肾病综合征(NS)患者血脂、载脂蛋白及脂蛋白(a)[LP(a)]水平的关系及LP(a)增高的机理。方法:对96例原发性NS和87例慢性肾小球肾炎患者的血脂、LP(a)及载脂蛋白水平进行测定和分析。结果:NS患者的LP(a)为(751.0±517.0)mg/L,较慢性肾小球肾炎组(196.0±170.0)mg/L明显升高(P<0.001)。NS组患者的总胆固醇、低密度脂蛋白、载脂蛋白B均显著增高,并与LP(a)呈正相关(r分别为0.41、0.46、0.38,P<0.01),与血浆白蛋白浓度呈负相关(r=-0.54,P<0.01)。结论:肾病综合征患者血LP(a)、血脂及载脂蛋白明显升高的主要原因是合成增加,LP(a)属于被动升高。

Objective： To study the level of blood fat, apolipoprotein and lipoprotein（a） and the relation between NS and chronic glomerulonephritiS （CG）, and the principle about lipoprotein（a） increasing. Methods： To analyze the clinical data from 96 NS patients and 87 CG. Results： The LP（a） level of Ns patients was （751±517）mg/L,which was greater than that of CG （196±170） mg/L （P 〈0. 001）, the level of total cholesterol, low density lipoprotein （LDL） and apoprotein-B were significant increasins, which had the positive correlation with LP（a） level （r = 0. 41,0. 46 ,0. 38 ,P 〈0.01） and the negative correlation with the concentrate of blood plasma albumin （r =- 0.54, P 〈0.01）. Conclusion： The blood fat, apolipoprotein and LP（a）, level of NS patients significantly increased, the main reason of it is the increase of synthesis, the increase of LP（a） is passive.