非酒精性脂肪性肝病相关因素分析

Analysis of the Relevant Factors of Nonalcoholic Fatty Liver Disease

目的：探讨非酒精性脂肪性肝病（Nonalcoholic fatty liver disease，NAFLD）的相关因素，提高对NAFLD的认识。方法：对进行常规体检的1836例体检者进行身高、体重、血压、血脂、血糖、肝脏功能及肝脏超声检查，提取NAFLD者的临床资料与非NAFLD者进行对照分析。结果：1836例体检者共检出NAFLD222例，占12．09％。其中，血清转氨酶增高者55倒，占24．77％，脂肪性肝硬化3例，占1．35％。年龄28岁～77岁，平均54．6岁，明显高于非NAFLD者的平均年龄38．8岁（P〈0．05）。男性108例，占48．65％；女性114例，占51．35％，排除性别构成的影响，男性NAFLD的患病率为12．05％，女性NAFLD的患病率为12．13％。两者比较，差异无统计学意义（P〉0．05）。NAFLD组与非NAFLD组比较，NAFLD组肥胖、高血糖、高血脂所占比例明显高于非NAFLD组（P〈0．05），而高血压者所占比例在两组无显著差异（P〉0．05）。结论：NAFLD的发生与年龄、肥胖、高血糖、高血脂有密切关系，临床上应加强对其相关因素的干预，预防NAFLD的发生。

Objectives： To investigate the relevant factors of nonalcoholic fatty liver disease （ NAFLD）, and to improve the cognition to NAFLD. Methods： 1836 cases carried out routine physical examination. The height, the body weight, the blood pressure, the blood lipid, the blood sugar, the liver function and the liver ultrasound examination were performed in all cases. All data of NAFLD eases and cases without NAFLD was carried out comparative analysis. Results： 222 cases were diagnosed to suffer from NAFLD （12.09%）. Among of them, aminotransferase was increased in 55 cases （24.77%）, and 3 cases suffer from fatty cirrhosis of liver （1.35%）. The average age of the NAFLD cases was 54.6 years old and ranged from 28 to 77 years old, which was older than that of the cases without NAFLD （38.8 years, p 〈0.05 ）. 108 cases were male （48.65%） and 114 cases were female （51.35%）. The sex - adjusted prevalence rate of NAFLD for male was 12.05%, and for females 12.13%. There was not different significance between male and female （ p 〉 0.05 ）. The proportions of obesity, hyperglycemia and hyperlipidemia in the NAFLD cases were significantly higher than those in the cases without NAFLD （ all p 〈 0.05 ）. But the proportion of hypertension between the tow groups have no difference （ p 〉 0.05 ）. Conclusions： The attack of NAFLD is related with age, obesity, hyperglycemia and hyperlipidemia. It should reinforce intervention on the relevant factors in clinic to prevent the attack of NAFLD.