缬沙坦预适应在大鼠急性缺血再灌注中的心肌保护作用

The Study of Myocardial Protection and Its Mechanisms of Valsartan Preconditioning in the Ischemic and Reperfused Rat Hearts

目的探讨缬沙坦预适应在大鼠心脏急性缺血再灌注中的心肌保护作用及机制。方法将40只SD大鼠随机分为5组(每组8只):模型对照组(C组),心梗对照组(M组),预适应后心梗组(I组),缬沙坦预适应组(AI组),缬沙坦心梗组(AM组)。2周后建立体内急性缺血再灌注心脏模型,监测缺血再灌注前后血中IL-6表达结果,以判断缬沙坦在预适应中的作用。结果缬沙坦预适应组较心梗组IL-6表达减少,与预适应组无统计学差异。结论缬沙坦预适应对体内大鼠心脏急性缺血再灌注时具有心脏保护作用。

Objective To investigate the protective effectof valsartan on the ischemic and reperfused rat myocardium and its mechanism. Methods Fourty Sprague-Dawley male rats were randomly and evenly divided into five groups：model control group; Ischemia-reperfusion group;Valsartan group treated with 5 nag valsartan per a kiogram once day. Rat models of I/R wew established with coronary occlusion 5 mintues and repeffusion 5 mintues of the left anterior descending artery after two - week＇s administration.At the end of repeffusion,the blood sample was taken and the plasma concentrations of IL- 6 were measured with enzyme - linked immunosorbent assay（ELISA） system.Results In comparison with model control group, the level of IL- 6 was decreased in valsartan group （ P 〈 0.05）. Conclusion Valsartan may have the protective effect on the ischemic rat myocardium.