摘要
目的探讨儿茶酚胺对大鼠血管内皮分泌功能的影响。方法利用大鼠异丙肾上腺素(ISP)心肌损伤模型,采用放免的方法测定血中内皮素(ET-1),前列腺素代谢产物6-酮前列腺素F1α(6-keto-PG1α)和血栓素B2(TXB2)的含量。结果试验组ISP导致血浆中ET-1明显增高;6-keto-PG1α含量明显降低而TXB2的含量明显增高。结论异丙肾上腺素损伤血管内皮分泌功能,从而可能影响血管的舒缩功能、血小板的凝血与止血的平衡状态,进一步导致心肌损伤及其他脏器的损伤。
Objective The effect of Isoproterenol on endocrine function of endothelial ceils in rat had been studied in the paper. Methods The radio-immunology assay was used to detect the radio-immune activity of ET- 1,6 - keto - PG1α and TXB2 in the plasma in the ISP myocardial damage model. Results ISP ean increase the radio - immune activity of ET - 1,6 - keto - PG1α and decrease the radio - immune activity of TXB2 in rat serum. Conclusion ISP can result in endothelial function damage that may play an important role in the development of thromohlic and vascular disease.
出处
《黑龙江医学》
2007年第5期347-348,共2页
Heilongjiang Medical Journal
