苯那普利联合氯沙坦治疗慢性充血性心衰的疗效分析

Curative Effect of Benazepril plus Losartan in Treating Chronic Congestive Heart Failure

目的探讨苯那普利联合氯沙坦治疗慢性充血性心衰(CHF)的临床疗效。方法选择26例CHF病人,心功能NYHAⅡ～Ⅳ级,随机分为两组:苯那普利组和苯那普利联合氯沙坦组。观察治疗前后临床症状、体征、心胸比率、左室舒张末内径(LVDd)和左室射血分数(LVEF)。结果两组改善心功能的效果无显著性差异,苯那普利联合氯沙坦组总有效率88.9%;苯那普利组总有效率为87.5%,P>0.05。但对心脏结构和功能改善的效果,苯那普利联合氯沙坦组优于苯那普利组,有显著性差异,P<0.05。而且血清钾、肌酐无明显变化,未出现严重副反应。结论苯那普利联合氯沙坦治疗CHF的效果比单用苯那普利的临床疗效好。

Objective To discuss the curative effect of Benazeprll plus Losartan in treating chronic congestive heart failure. Methods 26 patients with chronic congestive heart failure,whose heart functions ranged from Class Ⅲ to Class Ⅳ（NYHA） , were selected and randomly divided into 2 groups：Group with Benazepril and Group with Benazepril plus Losartan;the clinical symptoms,physical signs, cardiothoracic ratio （CTR）, LVDd and LVEF were observed, Results There was no significant difference in the improvement of heart function （NYHA） between the 2 groups, the total effective rate of Group with Benazepril plus Losartan was 88.9% while that of Group with Benazepril was 87.5% （ P 〉 0. 05 ） ; the effect on heart constitution and function improvement of Group with Benazepril plus Losartan was significantly superior to that of Group with Benazepril （ P 〈 0. 05 ） ; no severe side effect and obvious change of serum potassium and creatinine were found in both groups. Conclusions The curative effect of Benazepril plus Losartan is better than that of Benazeprll in treating chronic congestive heart failure.