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S100A6的转录调控及其与肿瘤关系的研究进展 被引量：2

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摘要 S100蛋白家族是一类非泛素化、EF-手型钙结合蛋白，通过与钙离子及靶蛋白的相互作用，在体内发挥多种生物学作用，参与细胞周期活动、细胞分化、肿瘤生长以及细胞外基质分泌活动等过程。其分布具有细胞、组织特异性。其中多个成员在肿瘤中表达异常，并与肿瘤的增殖、浸润转移和凋亡密切相关，其中包括S100A6。S100A6又称为钙周期蛋白（Calcyclin，Cacy），过去也称为2A9、5810、PRA和CACY。
作者 苗静琨 周兰
机构地区 重庆医科大学生物医学工程系
出处 《重庆医科大学学报》 CAS CSCD 2007年第7期779-781,共3页 Journal of Chongqing Medical University
基金 国家自然科学基金(30340039) 2003年教育部"春晖计划"科研启动经费资助项目 2004年重庆市留学回国人员启动基金。
关键词 S100A6 肿瘤关系 转录调控 钙结合蛋白 S100蛋白 细胞周期 生物学作用 细胞外基质
分类号 R758.63 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献22

  • 1姬峻芳.S100蛋白家族与肿瘤[J].国外医学（肿瘤学分册）,2002,29(4):261-263. 被引量：18
  • 2Donato R.Intracellular and extracellular roles of S-100 proteins[J].Microsc Res Tech,2003;60(6):540-551.
  • 3Donato R.S100:a muhigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles[J].Int J Biochem Cell Biol,2001;33(7):637-668.
  • 4Ethan DE,Leigh CM,Peter HW.S100 proteins and their influence on pro-survival pathways in cancer[J].Int Biochem Cell Biol,2004;82:508-515.
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  • 8Lesniak W,Szczepanska A,Kuznicki J.Calcylin (S100A6) expression is stimulated by agents evoking oxidative stress via the an tioxidant respose element[J].Biochim Biophys Acta,2005;1744(1):29-37.
  • 9Joung Hyuck Joo,Jae Wha Kim,Younghee Lee,et al.Involvement of NF-κB in the regulation of S100A6 gene expression in human hepatoblastoma cell line HepG2[J].Biochem Biophys Res Commun,2003;307:274-280.
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二级参考文献21

  • 1Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracelluar and extracellular functional roles[J]. Int J Biochem Cell Biol, 2001, 33(7): 637-668.
  • 2Watson PH, Leygue ER, Murphy LC. Psoriasin(S100A7)[J]. Int J Biochem Cell Biol, 1998, 30(5): 567-571.
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共引文献17

同被引文献32

  • 1张丽君,刘银坤,朱运松.钙结合蛋白S100A6基因的研究进展[J].国外医学（临床生物化学与检验学分册）,2004,25(6):542-544. 被引量：4
  • 2Ji YF, Huang H, Jiang F, et al. S100 family signaling network and related proteins in pancreatic cancer[ J]. Int J Mol Med, 2014 , 33 (4) : 769-776.
  • 3Raponi M, Zhang Y, Yu J, et al. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung[ J ]. Cancer Res, 2006, 66 (15): 7466-7472.
  • 4Ettinger DS: Ten years of progress in non-small cell lung cancer [J]. J Natl Compr Canc Netw, 2012, 10(3) : 292-295.
  • 5Nan Y, Jin F, Yang S, et al. Discovery of a set of biomarkers of human lung adenocarcinoma through cell-map proteomics and bioinformatics[ J]. Med Oncol, 2010, 27 (4) : 1398-1406.
  • 6Lesniak W, Slomnicki LP, Filipek A. S100A6-new facts and features[J]. Biochem Biophys Res Commun, 2009, 390 (4) : 1087-1092.
  • 7Filipek A. S100A6 and CacyBP/SIP - two proteins discovered in ehrlich ascites tumor cells that are potentially involved in the degradation of beta-catenin[ J]. Chemotherapy, 2006, 52( 1 ) : 32- 34.
  • 8Lesniak W, Swart GW, Bloemers HP, et al. Regulation of cell specific expression of calcyelin ( S100A6 ) in nerve cells and other tissues [ J ]. Acta Neurobiol Exp ( Wars), 2000, 60 (4) : 569-575.
  • 9Schneider G, Filipek A. S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP) : spotlight on properties and cellular function [J]. Amino Acids, 2011 , 41(4) : 773-780.
  • 10Emberley ED, Murphy LC, Watson PH. S100 proteins and their influence on pro-survival pathways in cancer [ J ]. Biochem Cell Biol, 2004, 82(4) : 508-515.

引证文献2

二级引证文献4

重庆医科大学学报
2007年 第7期

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