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贝伐单抗靶向治疗结直肠癌的临床研究进展 被引量：1

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摘要 分子靶向治疗已成为结直肠癌治疗的有效策略。最近，血管生成抑制疗法日益成熟，针对血管内皮生长因子（VEGF）的重组人源化单克隆抗体贝伐单抗（bevacizumab，商品名：Avastin，阿瓦斯丁^TM）成为结直肠癌治疗研究的热点。美国食品药品管理局（FDA）于2004年批准贝伐单抗为晚期结直肠癌的一线用药，
作者 靳西凤 冉志华
机构地区 上海交通大学医学院附属仁济医院上海市消化疾病研究所
出处 《胃肠病学》 2007年第5期305-307,共3页 Chinese Journal of Gastroenterology
关键词 晚期结直肠癌 分子靶向治疗 贝伐单抗 临床研究 美国食品药品管理局 人源化单克隆抗体 血管内皮生长因子 AVASTIN
分类号 R735.3 [医药卫生—肿瘤]
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参考文献22

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  • 2Lee JC,Chow NH,Wang ST,et al.Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients.Eur J Cancer,2000,36 (6):748-753.
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  • 8封宇飞,雷静,傅得兴.血管内皮生长因子抑制剂——贝伐单抗[J].中国药学杂志,2005,40(19):1519-1520. 被引量：10
  • 9Kabbinavar F,Hurwitz HI,Fehrenbacher L,et al.Phase Ⅱ,randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer.J Clin Oncol,2003,21 (1):60-65.
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二级参考文献10

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  • 7Kabbinavar F, Hurwitz HI, Fehrenbacher L, etal, Phase Ⅱ, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin(LV) with FU/LV alone in patients with metastatic colorectal cancer[J]. J Clin Oncol , 2003, 21(1):60.
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胃肠病学
2007年 第5期

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