有心肌梗塞家族史儿童血清脂蛋白(a)的研究

A study on serum lipoprotein(a) in children with family history of myocardial infarction

为探讨有心肌梗塞家族史的少年儿童血脂的改变，特别是脂蛋白（ａ）的改变，采用单克隆抗体酶联免疫吸附实验，对３３例有心肌梗塞家族史的少年儿童测定其脂蛋白（ａ）［Ｌｐ（ａ）］。结果：血清Ｌｐ（ａ）＞３００ｍｇ／Ｌ：心肌梗塞家族史阳性的３３例中有１６例（４８％），而对照组３３例中只有５例（１５％）（χ２＝８．５４０，Ｐ＜０．０５）；有心肌梗塞家族史儿童的血清Ｌｐ（ａ）含量明显高于对照组。提示：对有心肌梗塞家族史的后代，应适时检测Ｌｐ（ａ），及早施行干预措施，以达到预防的目的。

To study the changes of blood lipid, especialy lipoprotein (a) , in children with family history of myocardial infarction, we used enzyme linked immunosorbent assay (ELISA) to determine Lp(a) and oxidized low density lipoprotein (OXLDL). Meanwhile, we also tested total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apoliprotein A (apoA) and apoB. We found that the level of Lp(a) markedly increased in children with family history of myocardial infarction as compared with normal controls. In conclusion, it is necessary for the children with family history of myocardiac infarction to have a timely test for Lp(a). Early medical intervention is needed for the sake of prevention.