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Hepatic venous outflow reconstruction in adult right lobe living donor liver transplantation without middle hepatic vein 被引量:28

Hepatic venous outflow reconstruction in adult right lobe living donor liver transplantation without middle hepatic vein
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摘要 Background It is difficult and challenging to reconstruct hepatic venous outflow in adult right lobe living donor liver transplantation (LDLT) without the middle hepatic vein (MHV). Excessive perfusion of the portal vein and venous outflow obstruction will lead to acute congestion of the graft, ultimately resulting in primary nonfunction. Although various reconstruction patterns have been explored in many countries, there is currently no clear consensus. In this study we describe a technique to prevent "chocking" of the graft at the outflow anastomosis with the inferior vena cava (IVC) in LDLT using right lobe graft without the MHV. Methods A retrospective analysis was conducted on clinical data from 55 recipients undergoing LDLT using right lobe grafts without the MHV or reconstruction of hepatic venous outflow. The donor's right hepatic vein (RHV) was anastomosed with a triangular opening of the recipient IVC; the inferior right hepatic vein (IRHV), if large enough, was anastomosed directly to the IVC. The great saphenous vein (GSV) was used for reconstruction of significant MHV tributaries. Results No deaths occurred in any of the donors. Of the 55 recipients, complications occurred in 6, including hepatic vein stricture (1 case), small-for-size syndrome (1), hepatic artery thrombosis (1), intestinal bleeding (1), bile leakage (1), left subphrenic abscess and pulmonary infection (1). A total of three patients died, one from small-for-size syndrome and two from multiple system organ failure. Conclusions The multiple-opening vertical anastomosis was reconstructed with hepatic vein outflow. This technique alleviates surgical risk of living donors, ensures excellent venous drainage, and prevents vascular thromboses and primary nonfunction. Background It is difficult and challenging to reconstruct hepatic venous outflow in adult right lobe living donor liver transplantation (LDLT) without the middle hepatic vein (MHV). Excessive perfusion of the portal vein and venous outflow obstruction will lead to acute congestion of the graft, ultimately resulting in primary nonfunction. Although various reconstruction patterns have been explored in many countries, there is currently no clear consensus. In this study we describe a technique to prevent "chocking" of the graft at the outflow anastomosis with the inferior vena cava (IVC) in LDLT using right lobe graft without the MHV. Methods A retrospective analysis was conducted on clinical data from 55 recipients undergoing LDLT using right lobe grafts without the MHV or reconstruction of hepatic venous outflow. The donor's right hepatic vein (RHV) was anastomosed with a triangular opening of the recipient IVC; the inferior right hepatic vein (IRHV), if large enough, was anastomosed directly to the IVC. The great saphenous vein (GSV) was used for reconstruction of significant MHV tributaries. Results No deaths occurred in any of the donors. Of the 55 recipients, complications occurred in 6, including hepatic vein stricture (1 case), small-for-size syndrome (1), hepatic artery thrombosis (1), intestinal bleeding (1), bile leakage (1), left subphrenic abscess and pulmonary infection (1). A total of three patients died, one from small-for-size syndrome and two from multiple system organ failure. Conclusions The multiple-opening vertical anastomosis was reconstructed with hepatic vein outflow. This technique alleviates surgical risk of living donors, ensures excellent venous drainage, and prevents vascular thromboses and primary nonfunction.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第11期947-951,共5页 中华医学杂志(英文版)
关键词 living donor liver transplantation right lobe graft living donors living donor liver transplantation right lobe graft living donors
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参考文献10

  • 1WANG Xue-hao,YAN Lü-nan,ZHANG Feng,LI Xiang-cheng,ZHU Ji-ye,PENG Zhi-hai,LIU Jin-hui,LI Guo-qiang,CHENG Feng,SUN Bei-cheng,GE Wen-gang.Early experiences on living donor liver transplantation in China: multicenter report[J].Chinese Medical Journal,2006(12):1003-1009. 被引量:7
  • 2Shah,SA,Levy,GA,Adcock,LD.Adult-to-adult living donor liver transplantation[].Canadian Journal of Gastroenterology.2006
  • 3Oya,H.,Sato,Y.,Yamamoto,S.,Takeishi,T.,Nakatsuka,H.,Kobayashi,T.,Hara,Y.,Hatakeyama,K.Surgical procedures for decompression of excessive shear stress in small-for-size living donor liver transplantation-new hepatic vein reconstruction[].Transplantation Proceedings.2005
  • 4Lee,S. G.,Hwang,S.,Park,K. M.,Kim,K. H.,Ahn,C. S.,Lee,Y. J.,Cheon,J. Y.,Joo,S. H.,Moon,D. B.,Joo,C. W.,Min,P. C.,Koh,K. S.,Han,S. H.,Choi,K. T.,Hwang,K. S.Seventeen adult-to-adult living donor liver transplantations using dual grafts[].Transplantation Proceedings.2001
  • 5Sugawara,Y.,Makuuchi,M.,Akamatsu,N.,Kishi,Y.,Niiya,T.,Kaneko,J.,Imamura,H.,Kokudo,N.Refinement of venous reconstruction using cryopreserved veins in right liver grafts[].Liver Transplantation.2004
  • 6Ghobrial,RM,Hsieh,CB,Lerner,S.Technical challenges of hepatic venous outflow reconstruction in right lobe adult living donor liver transplantation[].Liver Transplantation.2001
  • 7Lo CM,Fan ST,Liu CL,Wong J.Hepatic venoplasty in living-donor liver transplantation using right lobe graft with middle hepatic vein[].Transplantation.2003
  • 8Malago M,Molmenti EP,Paul A,et al.Hepatic venous outflow reconstruction in right live donor liver transplantation[].Liver Transplantation.2005
  • 9Diego Bogetti,Fabrizio Panaro,Tomasz Jarzembowski,Howard Sankary,Enrico Benedetti and Giuliano Testa.Hepatic venous outflow reconstruction in adult living donor liver transplants without portal hypertension[].Clinical Transplantation.2004
  • 10Kawasaki,S,Makuuchi,M,Matsunami,H,Hashikura,Y,Ikegami,T,Chisuwa,H,Ikeno,T,Noike,T,Takayama,T,Kawarazaki,H.Preoperative measurement of segmental liver volume of donors for living-related liver transplantation[].Hepatology.1993

二级参考文献2

  • 1Masatoshi Makuuchi M.D.,Charles M. Miller M.D.,Kim Olthoff M.D.,Myron Schwartz M.D.Adult-adult living donor liver transplantation[J].Journal of Gastrointestinal Surgery.2004(3)
  • 2Taisuke Morimoto,Masato Ichimiya,Akira Tanaka,Iwao Ikai,Yuzo Yanamoto,Yoshiaki Nakamura,Yasugu Takada,Yukihiro Inomata,Kazuo Honda,Takashi Inamoto,Koichi Tanaka,Yoshio Yamaoka.Guidelines for donor selection and an overview of the donor operation in living related liver transplantation[J].Transplant International.1996(3)

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