381例视网膜母细胞瘤侵及视神经的相关因素分析

Study on the risk factors for optic nerve invasion in 381 cases of retinoblastoma

目的探讨视网膜母细胞瘤（RB）侵犯视神经的相关危险因素。方法回顾性分析1990至2002年381例患儿的临床和病理资料，对其性别、年龄、眼别、病程、临床表现、临床分期及组织学分型与视神经侵犯程度进行分析。结果RB患儿视神经受侵犯的程度与病变临床分期、肿瘤组织学分型有一定关系（P〈0．01）。结论减少视神经受累的危险因素对RB的预后有重要意义。（中华眼科杂志．2007，43：489-492）

Objective To investigate the clinical and pathologic outcomes of a large group of retinoblastoma （RB） cases to ascertain the risk factors of RB optic nerve invasion. Methods In this paper, we summarized the clinical and pathologic data of 381 retinoblastoma cases in Beijing Tongren Hospital observed from 1990 to 2002. Statistical analyses were performed on the sex, age, unilateral or bilateral cases, length of symptoms, clinical situation, stage, histological type and the degree of optic nerve invasion. Results The degree of RB optic nerve invasion was closely correlated to clinical stage and tumor differentiation. Conclusion Avoiding the risk factors of RB optic nerve invasion is very important for the prognosis of RB. （Chin J Ophtbalmol , 2007,43：489-492 ）