摘要
以重组痘苗病毒作载体,探讨了关于VpuORF对人免疫缺陷病毒1型(HIV-1)Env蛋白合成和免疫原性的影响。结果表明,如果存在VpuORF,Env蛋白的合成降低,并且降低其产生抗Env抗体的水平。去掉VpuORF,不但提高Env蛋白的合成。
The effect of the Vpu ORF on the synthesis and immunogenicity of HIV 1 envelope proteins (Env) was studied on recombinant vaccinia vectors (RVVs). The results showed that the presence of Vpu ORF could reduce the amount of the Env proteins synthesized in vitro, resulting in the decreased production of anti HIV 1 antibodies induced by RVVs.
出处
《中国兽医学报》
CAS
CSCD
北大核心
1997年第1期21-25,共5页
Chinese Journal of Veterinary Science