摘要
以１７β－雌二醇－６－人血清白蛋白对新西兰公兔进行主动免疫，用ＲＩＡ检测抗体滴度和１７β－雌二醇及睾酮浓度，并检测睾丸重量和间质细胞面积。结果，试验组各兔均不同程度地产生了１７β－雌二醇抗体，其血浆１７β－雌二醇浓度极显著地低于对照组〔（２０．３±２１．６）ｎｇ／Ｌ，（１６７．７±４９．６）ｎｇ／Ｌ，Ｐ＜０．００１〕，睾酮浓度极显著地高于对照组〔（７．３±７．１）μｇ／Ｌ，（０．５２±０．２９）μｇ／Ｌ，Ｐ＜０．０１〕。每侧睾丸重量和间质细胞面积均极显著地大于对照组〔（３．９４±０．９３）ｇ和（２５２．２５±８５．７８）μｍ２，（２．９８±０．７２）ｇ和（１６１．７９±３６．４５）μｍ２，Ｐ＜０．０１和Ｐ＜０．００１〕。
In the male rabbits immunized with 17β oestradiol, the plasma concentration of 17β oestradiol have been measured to be significantly lower than those of controls (20 3±21 6) ng/L, (167 7±49 6) ng/L, P<0 001 , but the testosterone concentration significantly higher (7 3±7 1) μg/L,(0 52±0 29) μg/L, P<0 01 . Unilateral testis weight and Leydig cell area in treated rabbits were significantly higher than those in controls (3 94±0 93) g and (252 25±85 78) μm 2, (2 98±0 72) g and (161 79±36 45) μm 2, P<0 01 and P<0 001 . It suggested that active immunization against 17β oestradiol may be used to improve the reproductive performance in male animals.
出处
《中国兽医学报》
CAS
CSCD
北大核心
1997年第1期61-63,共3页
Chinese Journal of Veterinary Science
基金
国家自然科学基金
关键词
雌二醇
主动免疫
睾酮
间质细胞
睾丸
公兔
β oestradiol
active immunization
testosterone
Leydig cell
testis
male rabbit
