^18F-氟脱氧葡萄糖PET-CT诊断主动脉壁粥样硬化斑块的价值探讨

Explore the vaule of ^18F-fluorodeoxyglucose PET-CT imaging in atherosclerotic plaques of aorta wall

目的通过PET-CT明确18F-氟脱氧葡萄糖在主动脉壁粥样硬化斑块中摄取程度,探讨其临床价值。方法60例受检者,包括正常对照者6例,大动脉粥样硬化病例54例。测定主动脉壁粥样硬化部位标准化摄取值（SUV）和CT值,并依据CT值将54例主动脉壁局部18F-FDG高摄取的动脉粥样硬化病例分成3组,软斑块组CT值小于60HU,中等斑块组CT值介于60￣100HU之间,钙化斑块组CT值大于100HU。第4组为正常对照组。结果软斑块组42个测量部位的平均SUV为1.553±0.486;中等斑块组30个测量部位的平均SUV为1.393±0.296;钙化斑块组36个测量部位的平均SUV为1.354±0.189;正常对照组33个测量部位的平均SUV为1.102±0.141。多组之间比较差异具有统计学意义（F=678.909,P=0.000）;正常组与各斑块组比较差异具有统计学意义。结论18F-FDG在主动脉粥样硬化斑块中具有不同程度的摄取,其中软斑块对18F-FDG的摄取最高,提示18F-FDG PET-CT是诊断不稳定性主动脉粥样硬化斑块的有价值方法。

Objective To explore the clinical value of PET-CT for the diagnosis of unstable plaques in atherosclerotic lesions. Methods 60 cases underwent whole-body ^18F-FDG PET-CT were retrospectively evaluated, including 6 cases with normal control group and 54 cases with atherosclerotic plaques . 54 cases with SUV and CT value in atherosclerotic lesions of large arterial wall were detected retrospectively. 54 high ^18F-FDG uptake cases in atherosclerotic plaques were divided into three groups according the CT value： soft plaques group, intermediate plaques group, calcified plaques group. Group 4 was normal. Results In soft plaques group there were 42 sites whose average SUV was 1.553±0.486, in intermediate plaques group there were 30 sites whose average SUV was 1.393±0.296, in calcified plaques group there were 36 sites whose average SUV was 1.354±0.189, in normal control there were 33 sites whose average SUV was 1.102±0.141. The SUV showed significant difference among the four groups （F=678.909, P=0.000）. There were significant difference between normal^18F-FDG uptake group and high ^18F-FDG uptake groups. Conclusions ^18F-FDG had different degree high uptake in large atherosclerotic plaques, the soft plaques had the highest ^18F-FDG uptake among them. The results suggested that ^18F-FDG PET-CT had significant potential valuable in the diagnosis of unstable soft plaques in atherosclerotic lesions.