冠心病患者冠状动脉介入术前后内皮素变化的初步探讨

Preliminary discussion that the endothelin changed before and after percufaneous coronary intervention operation of coronary heart disease

目的观察冠状动脉介入术（PCI）前后内皮素（ET）水平与冠心病的关系。方法住院冠心病患者分别于PCI手术前3d、当日、术后0.5h、术后1d、术后3d从外周静脉采血,观测其ET水平的变化。结果术前3d及手术当日ET水平与正常对照组有显著差异,术后0.5h与正常对照组无明显差异,而术后1d及术后3d又比正常对照组明显升高;术后0.5h比术前明显下降,而术后1d及术后3d又与术前无明显差异。结论外周血中ET水平与冠心病患者的病情变化密切相关,但能否作为判断PCI术后病情好转及预后的指标还有待进一步的探讨。

Objective Observe the relation between endothelin and coronary heart disease around percufaneous coronary intervention （PCI） operation. Methods In hospital the coronary heart disease patients collected blood from the vein in 3 days before PCI operation, the same day , postoperative half an hour or 1 days or 3 days , observe the change of endothelin in plasma. Results There are obvious differences between the endothelin which in the normal control group and 3 days before operative or the same day, having nothing difference with the half an hour postoperative group, the endothelin which in 3 days or 1 day postoperative is obviously higher than the normal control group, the endothelin of half an hour postoperative is obviously lower than foreoporation, having statistics meaning, but 1 or 3 days postoporative is no difference with foreoporative. Conclusions The endothelin is closely with coronary heart disease , but if it could be as judging the index of the PCI postoperative taking a favorable turn and prognosis also needs the further discussion.