摘要
人类乳腺组织含有两种不同的上皮细胞：即腺腔内层的腺上皮细胞和外层的肌上皮细胞，前者表达细胞角蛋白（CK）8／18／19，而后者表达平滑肌肌动蛋白（SMA）。以往人们常常用它来解释正常乳腺组织的发育以及乳腺肿瘤的发生和发展。一般认为乳腺肿瘤均来源于腺上皮细胞，而乳腺癌中肌上皮细胞减少或消失，并以此来鉴别是否有浸润或癌变。这两种上皮细胞的起源一直受到学术界的关注。
出处
《中华病理学杂志》
CAS
CSCD
北大核心
2007年第6期423-425,共3页
Chinese Journal of Pathology
基金
北京大学人民医院院项研究及发展基金资助项目(P870)
参考文献24
-
1Kordon EC, Smith GH. An entire functional mammary gland may comprise the progeny from a single cell. Development, 1998,125 (10) :1921-1930.
-
2Lakhani SR, O' Hare MJ. The mammary myoepithelial cell-Cinderella or ugly sister? Breast Cancer Res,2001,3 ( 1 ) : 1-4.
-
3Bocker W, Moll R, Poremba C, et al. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages:a new cell biological concept. Lab Invest, 2002,82 (6) : 737-746.
-
4Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature ,2000,406 (6797) :747-752.
-
5Gudjonsson T, Villadsen R, Nielsen HL, et al. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev,2002,16(6) :693- 706.
-
6Wolman SR, Heppner GH, Wolman E. New directions in breast cancer research. FASEB J, 1997,11 (7) :535-543.
-
7Bocker W, Buerger H. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept. Cell Prolif,2003,36(Suppl 1 ) :73-84.
-
8Clarke CL, Sandle J, Parry SC, et al. Cytokeratin 5/6 in normal human breast: lack of evidence for a stem cell phenotype. J Pathol, 2004,204 (2) : 147 - 152.
-
9Al-Hajj M, Clarke MF. Self-renewal and solid tumor stem cells. Oncogene ,2004,23 (43) :7274-7282.
-
10Man YG, Tai L, Barner R, et al. Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion. Breast Cancer Res, 2003,5 (6) :R231-R241.
同被引文献13
-
1张景丽,张红英,魏兵,郎志强,步宏.细胞角蛋白在乳腺导管内增生性病变鉴别诊断中的应用[J].中华病理学杂志,2004,33(4):316-319. 被引量：9
-
2陈婷婷,孟刚,龚西騟.乳腺癌切除标本内导管内增生性病变的免疫表型观察[J].临床与实验病理学杂志,2006,22(1):11-18. 被引量：13
-
3郎志强,魏兵,步宏,张红英,李新军,陈卉娇.基底型细胞角蛋白在乳腺导管内增生性病变诊断中的应用[J].临床与实验病理学杂志,2006,22(1):19-23. 被引量：16
-
4阮秋蓉,刘聪,李力,葛晓娜,邓仲端.对乳腺导管内增生性病变临床病理的评估[J].诊断病理学杂志,2006,13(4):267-270. 被引量：6
-
5Kordon EC, Smith GH. An entire functional mammary gland may comprise the progeny from a single cell [ J ]. Development, 1998, 125 (10) : 1921 - 1930.
-
6Lakhani SR, O' Hare MJ. The mammary myoepithelial cell-Cinderella or ugly sister[ J ] ? Breast Cancer Res, 2001,3 ( 1 ) : 1 - 4.
-
7Bocker W, Moll R, Poremba C, et al. Conamon adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept [ J ]. Laboratory Investigation, 2002, 82 (6) : 737 - 746.
-
8Tavassoli FA, Devilee P. World Health Organization classification of tumors. Pathology and genetics of tumors of the breast and fence genital organs [ M ]. Lyon : IARC Press, 2003.63 - 67.
-
9Otterbach F, Bankfalvi A, Bergner S, et al. Cytokeratin5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast [ J ]. Histopathology, 2000, 37 ( 3 ) : 232 - 240.
-
10Boecker W, Buerger H, Schmitz K, et al. Ductal epithelial proliferations of the breast: a bioiogical continuum? Comparative genomic hybridization and high-molecular-weight cytokeralin expression pat terns [ J ]. J Pathol, 2001,195 ( 4 ) : 415 - 421.
-
1马文浩,韩玉贞.乳腺癌干细胞信号转导通路的研究进展[J].医学综述,2011,17(18):2759-2762. 被引量：3
-
2张斌,翟保平,李文涛.乳腺癌干细胞的研究现状[J].河南医学研究,2010,19(4):496-500.
-
3张众,李连宏,谢丰培.乳腺干细胞与乳腺癌干细胞研究及其临床意义[J].临床与实验病理学杂志,2008,24(1):6-11. 被引量：9
-
4林帅,吴诚义.BRCA 1与乳腺癌研究的进展[J].中国普通外科杂志,2009,18(5):501-504. 被引量：4
-
5李治,黄韬,贺艳丽,张家华,田元.对不同性质乳腺组织中乳腺干细胞比例的测定[J].华西医学,2006,21(3):442-444. 被引量：1
-
6柯玉华,胡胜,付小玉.乳腺干细胞和乳腺癌[J].中国肿瘤,2006,15(8):526-528. 被引量：3
-
7黄受方.乳腺“干细胞（CK5／6^＋）学说”与导管上皮良恶性增生的诊断[J].中华病理学杂志,2013,42(2):73-77. 被引量：3
-
8石爱平,许宁,范志民,张哲,王广义,王有德.成人乳腺干细胞中乳腺癌相关基因表达的研究[J].中国老年学杂志,2006,26(7):934-935. 被引量：4
-
9李伟东,崔力方,谷峰,付丽.乳腺干细胞和乳腺癌干细胞研究现状[J].中华乳腺病杂志（电子版）,2010,4(4):48-52. 被引量：1
-
10龚静青.p53调节乳腺干细胞的自我更新分裂的方向[J].中国病理生理杂志,2009,25(11):2196-2196.
