Ki-67在乳腺癌中的表达及相关性研究

Expression of Ki -67 and its correlative study in breast cancer

目的探讨乳腺癌中Ki-67表达与乳腺癌组织学类型、肿瘤大小、临床分期、淋巴结转移、雌激素受体（ER）、孕激素受体（PR）、p53、C-erbB-2表达的关系及临床意义。方法采用免疫组织化学方法检测73例乳腺癌Ki-67的表达，并分析其与临床指标的关系。结果Ki-67的阳性表达率为86．3％，Ki-67表达与肿瘤大小、淋巴结转移相关，与ER、PR、p53、C—erbB-2表达不相关，Ki-67过度表达与ER、PR、C—erbB-2、p53表达无明显相关性。结论Ki-67高表达是乳腺癌预后不良的指标，Ki-67表达的检测作为乳腺癌常规病理检查，可用于乳腺癌的预后判断及化疗敏感指标。

Objective To investigate the relationship and clinical significance between the expression of Ki - 67 and the histological types, tumor size, clinical stages, lymphatic metastasis, estrogen receptor （ER）, progesterone receptor （PR）, p53, C -erbB -2 in breast cancer. Methods The expression of Ki - 67 was detected by immunohistochemical technology in 73 cases of breast cancer and compared with clinical parameter. Results The positive expression rate of Ki - 67 was 86.3%. There were correlation between expression of Ki - 67 and tumor size, axillary lymphatic metastasis. No difference was observed between expression of Ki -67 and ER, PR, p53, C -erbB -2. There were no correlation between over expression of Ki - 67 and ER, PR, C - erbB - 2, p53. Conclusions High expression of Ki - 67 is the poor prognostic marker of breast cancer. Detection of Ki - 67 expression can be arranged as regular pathological examination in breast cancer and the results can be used for determining prognosis and sensitivity chemotherapy.