决明子、山楂提取物不同配比降血脂作用的研究

Study on Lipid-regulating Function for the Extracts and Their Prescriptions from Semen Cassiae and Fructus Crataegi

目的:探讨决明子提取物、山楂提取物不同配比对高脂小鼠血脂的影响。方法:雄性昆明小鼠80只,随机分成8组,给药组分别给予决明子提取物、山楂提取物以及二者不同配比的混合物,剂量为180 mg/kg,给药一周后,除正常对照组外,每组一次灌胃75%蛋黄乳液,24 h后测定血脂。结果:各给药组血清TC、TG、LDL-C和apoB与模型组相比均有不同程度降低,决明子提取物和山楂提取物混合使用时降脂作用增强(P<0.05,P<0.01),但对血清HDL-C和apoAI的含量没有明显的影响。结论:决明子提取物、山楂提取物混合使用时,其降脂作用比单一提取物要强。

Objective： To study the effect of lipid-regulating function for extracts and their prescriptions from Semen Cassiae and Crataegus pinnatifida Bgc. var. major N. E. Br. on serum lipid of hyperlipidema mice. Methods： 1 week after being administered with extract of Semen Cassiae, extract of Crataeg,s pinatifida Bge. vat. major N. E. Br. and different proportion mixture of them （ 180 mg/ kg） , mice were treated with ip 75% flesh yelkfluid. The contents of TC, TG, HDL-C, LDL-C, apo Al and apo B were observed after 24 h. Results ： The levels of TC, TG, I.DL-C and apoB in therapeutic group were lower than those in hyperlipidemic model group（ P 〈 0. 05, P 〈 0. 01 ） , especially in different proportion mixture groups. Conclusion ： Lipid-regulating active part of Semen Cassiae and Crataegus pinatifida Bge. var. major N. E. Br. might inhibit hyperlipidemic formation, and mixture groups were more effective than those of its single extract.