灯盏花素对创伤性脑损伤大鼠学习记忆功能的影响

Effects of Breviscapine on Learning and Memory Dysfunction of Rats Induced by Traumatic Brain Injury

目的观察灯盏花素对创伤性脑损伤大鼠学习记忆功能和脑氧自由基的影响。方法通过液压损伤法建立大鼠创伤性脑损伤模型,水迷宫实验和避暗实验测定大鼠学习记忆功能,并于测试后取脑测定总超氧化物歧化酶(T-SOD)、丙二醛(MDA)含量。结果在Morris水迷宫实验中,灯盏花素能明显缩短脑创伤大鼠逃避潜伏期;在避暗实验中,灯盏花素能显著延长脑创伤大鼠学习记忆潜伏期,减少错误次数。灯盏花素可以显著降低脑创伤大鼠脑组织MDA含量和显著增加T-SOD含量。结论灯盏花素可改善脑创伤大鼠学习记忆功能,其作用与抑制氧自由基反应有关。

Aim To study the effects of breviscapine on cognitive function after traumatic brain injury （TBI） in rats. Methods Rat traumatic brain injury was made by fluid percussion brain injury method. The learning and memory function was evaluated using the Morris water maze test and passive avoidance test. Total superoxide dismutase （T-SOD） and malondialdehyde （MDA） in brain tissues were measured after the cognitive function test. Results Breviscapine can significantly shorten the escape latent period of TBI rats in Morris water tests, extend the latent period of learning and memory of TBI rats and decrease the frequency of errors in passive avoidance tests. Breviscapine significantly decreased MDA content and increased T-SOD content in brain tissues. Conclusion Breviscapine can improve cognitive dysfunction after TBI in rats, and its protective effect was related to the decreasing oxidative stress in brain tissues.