急诊血液灌流救治急性毒鼠强中毒的疗效观察

Efficacy of emergency hemoperfusion therapies in patients with acute tetramine poisoning

目的探讨急诊血液灌流对急性毒鼠强中毒的治疗价值。方法根据患者法定监护人的选择,36例急性毒鼠强中毒患者分为单纯内科综合治疗组(治疗组)和血液灌流组(灌流组)。在内科综合治疗的基础上,采用血液灌流救治21例,并与单纯内科综合治疗的15例为对照,比较患者血清中毒鼠强浓度及意识清醒时间和抽搐停止时间。结果血液灌流治疗后患者血清毒鼠强浓度、患者意识清醒时间和抽搐停止时间较常规治疗组均明显降低(P<0.05);经治疗相同时间后,灌流组灌流前和灌流后即刻血清毒鼠强浓度从(190.5±16.3)ng/L下降到(121.6±15.2)ng/L,而常规治疗组从(191.4±18.2)ng/L下降到(146.1±19.4)ng/L,两组浓度下降值比较有显著差异(P<0.05)。结论血液灌流救治急性毒鼠强中毒较单纯内科综合治疗疗效显著,值得推广使用。

Objective To explore the efficacy of emergency hemoperfusion therapies in patients with acute tetramine poisoning. Methods Thirty six patients with acute tetramine poisoning were divided into routine medical therapy group（ control group） and hemoperfusion group according to the choice of patients＇ legal guardians. Base on routine medical therapy, 21 patients were treated with emergency hemoperfusion, and compared with 15 patients treated with routine therapy. Blood concentration of tetramine, recovery time and convulsion termination time were compared. Results Blood concentrations of tetramine, the time for consciousness recovery and convulsion termination in patients with hemoperfusion were significantly lower than those in patients with routine therapy（ P 〈 0.05 ）. Treated after the same period of time, blood concentration of tetramine in hemoperfusion group decreased from （ 190.5 ±16.3 ） ng/L to （ 121.6 ± 15.2） ng/L, and control group decreased from （ 191.4 ± 18.2） ng/ L to （ 146. 1 ± 19.4） ng/ L. The degree of reduction was significant （ P 〈 0.05 ）. Conclusion The efficacy of hemoperfusion therapy are satisfactory.