摘要
以对苯胺、丙二酸二乙酯为原料、吡啶为溶剂合成N,N'-二苯基丙二酰胺的方法进行了研究。最佳工艺条件为:原料摩尔比苯胺∶丙二酸二乙酯=2.4∶1.0,吡啶用量为苯胺质量的50%,反应时间为2h,反应温度为115℃,在DMF中进行重结晶,收率达92%以上,产品纯度为99%以上。
The method of synthesizing N,N′-diphenylmalonamide employing aniline and malonic ester and pyridine as extractant was investigated. The optimum conditions were as follows：the molar ratio of aniline to malonic ester was 2.4：10, the amount of pyridine was 50%（base on the mass of aniline）, the reaction time was 2 hours and the reaction temperature was 115℃, recrystallisation in DMF.Under these conditions the yield of N,N′-diphenylmalonamide was over 92% ,and the pure was up to 99% by HPLC analysis.
