盐酸帕罗西汀治疗躯体形式障碍临床研究

Clinical studies of paroxetine hydrochloride in the treatment of somatoform disorder

目的观察盐酸帕罗西汀治疗躯体形式障碍的临床疗效。方法对75例躯体形式障碍患者给予盐酸帕罗西汀口服治疗,剂量20 mg,每日1次,早餐后服用,疗程4周。于治疗前及治疗4周末采用抑郁自评量表评定临床疗效,并对用药后不良反应进行分析。结果治疗前后抑郁自评量表评分比较差异有统计学意义（P〈0.05）,临床总显效率81.3%,躯体症状较治疗前有显著性改善（P〈0.05）。结论盐酸帕罗西汀治疗躯体形式障碍疗效显著,安全性高,依从性好。

Objective To observe clinical effectiveness of paroxetine hydrochloride in the treatment of somatoform disorders. Methods Sevety -five patients with somatoform disorders were theated with paroxetine hydrochloride,20 mg/d orally took after breakfast for 4 weeks. Clinical effectiveness was assessed with the Self-rating Depression Scale （SDS） before treatment and at the end of 4th treatment, and the adverse effects were analyzed. Results There was significant difference in the SDS between pre and post - treatment （ P 〈 0. 05 ）,clinical effectual rate was 81.3%, after treatment, somato -symptoms significantly improved （ P 〈 0. 05 ）. Conclusion Paroxetine hydrochloride has significant effects, higher safty and better compliance in the treatment of somato - symptoms.