期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

广东地区宫颈癌HPV52型L1基因突变分析 被引量：2

下载PDF
导出
摘要 目的调查我国广东地区宫颈癌患者组织中HPV52型的感染率及L1基因突变特性,为制备适合中国人群的疫苗提供流行病学资料。方法采用HPV通用引物对130例宫颈癌标本中的HPVL1区基因序列进行PCR扩增,并结合基因测序分析。结果获得HPV52型8例,检出率为6.15%,对所获得的各例HPV52L1基因测序分析。结论与Genbank标准株相比,广东地区发现的HPV52L1基因有多处突变,与香港发现的HPV52突变株相近。
作者 曾莉 郭遂群 云径平 谢波 俞守义
机构地区 南方医科大学公共卫生与热带医学学院 南方医科大学南方医院妇产科 华南肿瘤学国家重点实验室 广东省第二中医院妇产科
出处 《广东医学》 CAS CSCD 北大核心 2007年第6期906-907,共2页 Guangdong Medical Journal
关键词 人类乳头瘤病毒 宫颈癌 L1基因 突变
分类号 R733.72 [医药卫生—肿瘤]
  • 相关文献

参考文献3

二级参考文献40

  • 1刘宝印,李洁,De,李力,龚林,王宏,杨学志,林玉纯.我国人乳头瘤病毒58型感染与宫颈癌的关系[J].中华实验和临床病毒学杂志,1996,10(2):118-121. 被引量：15
  • 2Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer[J]. N Engl J Med, 2003,348:518-527.
  • 3Bosch FX, Manos MM, Munoz N ,et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective[J]. Cancer Inst. 1995.87:796-802.
  • 4Lei HG, Sun CA, Yu MH, et al. Favorable clinical outcome of cervical cancers infected with human papillomavirus type 58 and related types [ J ]. Int J Cancer, 1999,84:553 - 557.
  • 5Lo WK, Wong YF, Chan KM, et al. Prevalence of papillomavirus in cervical cancer: a multicenter study in China [ J ]. Cancer,2002,100:327-331.
  • 6Ranst MV, Kaplan JB, Burk RD. Phylogenic classification of human papillomaviruses: correlation with clinical manifestations [ J ].J Gen Virol. 1992,73:2653-2660.
  • 7Chan SY, Delius H, Halpem AL, et al. Analysis of genomic sequences of 95 papillomavirus types : uniting typing, phylogeny, and taxonomy[J]. J Virol, 1995,69:3074-3083.
  • 8Jacobs MV, Husman AR, Brule A.I, et al. Group-specific differentiation between high-and low-risk human papillomavims genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes[J]. J Clin Microbiol, 1995,33:901-905.
  • 9Gallo G, Bibbo M, Bagella L, et al. Study of viral integration of HPV-16 in young patients with LSIL[J]. J Clinic Pathol, 2003,56:532- 536.
  • 10Schwarz E, Frccse UK, Gissraann L, et al. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells[J]. Nature, 1985,314 : 111-114.

共引文献80

同被引文献11

  • 1陶萍萍,卞美璐,李敏,刘军.HPV多重感染与宫颈病变关系探讨[J].中国妇产科临床杂志,2006,7(2):94-96. 被引量：112
  • 2Pankin DM, Pisan IP, Ferlay J. Estinates of the world wide incidence of 25 major cancers[J], lnt Cancer, 2007,80(6) : 827- 841.
  • 3McLaughlin-Drubin ME, Manger K. Oncogenie activities of human papillomaviruses [ J ]. Vires Res, 2009, 143 (2) : 195-208.
  • 4Chen W, Zhang X, Molijn A, et al. Human papillomavirus type- distribution in cervical cancer in China: the importance of HPV 16 and 18 [ J ]. Cancer Causes Control, 2009,20 ( 9 ) : 1705 -1713.
  • 5Milde-Langoseh K, Riethdorf S, L ning T. Association of human papillomavirus infection with carcinoma of the cervix uteri and its precursor lesions: theoretical and practical implications[J]. Virchows Arch, 2000,437(3) :227-233.
  • 6Bulk S, Berkhof J, Bulkmans NW, et al. Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in the Netherlands[ J ]. Br J Cancer, 2006, 94 ( 1 ) : 171-175.
  • 7Munoz N, Bosch FX, de-Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer[J]. NEJM, 2003, 348(6) :518.
  • 8Bao YP, Li N, Smith JS, et al. Human papillomavirus type distribution in women from Asia: a meta-analysis[ J]. Int J Gynecol Cancer, 2008,18 ( 1 ) :71-79.
  • 9IAu X, Zhang S, Ruan Q, et al. Prevalence and type distribution of human papillomavirus in women with cervical lesions in Liaoning Province, China[J]. lnt J Gynecol Cancer, 2010, 20( 1 ):145'- 153.
  • 10Chang DY, Chen RJ, Lee SC, et al. Prevalence of single and multiple infection with human papillomaviruses in various grades of cervical neoplasia[ J]. j Med Microbiol, 1997, 46( 1 ) :54-60.

引证文献2

二级引证文献16

广东医学
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部