血浆D-二聚体测定对诊断下肢深静脉血栓形成的临床意义

Clinical significance of plasma D-dimer assay in diagnosis of deep vein thrombosis in lower limbs.

目的评估测定血浆D-二聚体含量在诊断急、慢性下肢深静脉血栓形成(DVT)中的价值。方法应用免疫测定法检测100例经连续彩色多普勒超声和B型超声诊断为DVT患者的血浆D-二聚体含量和对照组100例下肢大隐静脉曲张患者(术前均经彩色多普勒超声检查深静脉通畅,排除DVT)血浆D-二聚体含量。结果DVT组和对照组血浆D-二聚体含量分别为(2.8±2.1)和(0.2±0.1)mg/L,2组差异有统计学意义(P<0.01);DVT组急性和慢性期血浆D-二聚体含量分别为(2.2±1.8)和(0.8±1.1)mg/L,2组差异有统计学意义(P<0.01)。结论血浆D-二聚体测定可用于DVT的临床诊断。

Objective To evaluate the measurement of plasma D-dimer level in the diagnosis of acute and chronic deep venous thrombosis （DVT） of the lower limbs. Methods Immunoassay method was used to detect D-dimer in the plasma in 100 patients with DVT of the lower limbs and in 100 patients with no DVT of the lower limbs confirmed by color continuous wave Doppler ultrasound and B-mode ultrasound. Results The plasma D-dimer level in patients with DVT and without DVT were （ 2.8 ± 2.1 ） mg/L and （ 0.2 ± 0.1 ） mg/L, respectively （ P 〈 0.01 ）. In patients with acute and chronic DVT, the plasma D-dimer levels were （ 2.2 ± 1.8 ） mg/L and （ 0.8 ± 1.1 ） mg/L, respectively （ P 〈0.01 ） Conclusion Plasma D-dimer assay is a rapid and simple noninvasive technique for the diagnosis of DVT.