2,2-二甲基丙酰氯工业生产的新方法

A New Industrial Process for Production of 2,2-Dimethylpropionyl Chloride

实现了异丁醇与85％的甲酸在浓硫酸作用下制备2，2－二甲基丙酸，再经三氯化磷酰化合成2，2－二甲基丙酰氯的工业化生产，提出了纯化酸的新方法，粗酸于低温下析出结晶，经离心分离得到纯度为99％的固体酸，长期放置无颜色变化。其酰化得到的酰氯颜色稳定，且该酰化收率提至87．2％。

A new indtistrial process for the productinn of 2,2-dimethyropiony1 chloridehas been successfully developed. 2,2-Dimethylpropanoic acid (Ⅰ) is first produced by the re-action of isobutanol with 85% formic acid in the presence of concentrated sulfuric acid. 99%Pure Ⅰ crystals that stay colorless for a long tim can be produtal when crude Ⅰ is cooled atlow temperature and then seperated by centrifugation. Colorless 2,2-dimethylpropionyl chlorideis produced by aopation of Ⅰ with PCl3 at 87.2% yield.