达斡尔民族X染色体遗传多态性与亲缘的关系

Genetic structure of X-STR loci of Daur populations and its affinities to other populations

目的:研究达斡尔民族X染色体遗传结构与亲属关系.方法:选择9个X-STR(DXS6804,DXS7133,DXS101,DXS6789,DXS6799,DXS7423,HPRTB,DXS8378,DXS7132),分析其多态性分布及与其他群体间的遗传距离和聚类关系.结果:研究群体中共检出51种等位基因,频率分布在0.0161～0.6935;基因型频率、杂合度、个体识别率、多态性信息量等群体遗传学指标分析显示,9个STR位点可用于群体遗传学研究和法医学应用;聚类分析和系统进化关系分析发现达斡尔和鄂伦春族有较近的遗传距离.结论:此9个X-STR位点具有较高的个体识别率和多态性信息量,可用于群体遗传学研究、法医学应用和疾病连锁分析.

AIM： To investigate the X chromosome＇s genetic structure of Daur population and its affinities to other populations. METHODS： We chose 9 X-STR （DXS6804, DXS7133, DXS101, DXS6789, DXS6799, DXS7423, HPRTB, DXS8378, DXS7132） as genetic markers to investigate the genetic diversity of Danr in Inner Mongolian. Cluster analysis and phylogenic trees showed the genetic distance among the populations. RESULTS： We got 51 alleles in the studied population, with the frequency between 0. 0161 - 0. 6935. Genotype frequency, heterozygosity （H）, the power of discrimination （ PD ） and the polymorphism information content （PIC） were acquired; Cluster analysis and phylogenic trees demonstrated the genetic affinity between Daur and Oroqen Populations. CONCLUSION： The genetic information reveals that the 9 chosen gene markers are highly informative loci and suitable for population genetic research, forensic application and disease association and linkage study.