妊娠期肝内胆汁淤积症111例分析

A clinical analysis of 111 cases of intrahepatic cholestasis of pregancy

目的了解妊娠期肝内胆汁淤积症的临床表现和妊娠结局,探讨妊娠期肝内胆汁淤积症对母儿的危害。方法对111例妊娠肝内胆汁淤积症作回顾性研究。结果妊娠肝内胆汁淤积症相关危害因素中,导致早产为首位,发生率为17.1%,次为胎膜早破(9.1%),自然流产(8.1%)等。肝功转氨酶有不同程度的升高。分娩方式以剖宫产为主,早产剖宫产率高于足月产,以单纯胆淤为首要手术指征,占68.5%。结论妊娠肝内胆汁淤积症对母儿危害较大,但经过积极治疗,预后良好。

Objective To investigate manifestations of intrahepatic cholestasis of pregnancy（ICP） and pregnancy outcomes of the patient and to explore its harmfulness to the fetus and the maternity. Methods The data of 111 cases of ICP were retrospectively analyzed. Results The incidence rate of premature labor caused by ICP was the highest （ 17. 1% ）, the incidence rates of premature rupture of fetal membranes and abortion caused by ICP （9.1% and 8.2% respectively） were the second. 92.9% of maternity had varied degree of elevated serum aminotransferase level. Majority of pregnant women received cesarean section, especially those in the premature labor group （68.5%）. The simple cholestasis was major operation indication. Conclusion Intrahepatic cholestasis of pregnancy is harmful to the mother and the fetus. But the prognosis of the disease is good after effective treatment.