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环氧合酶-2及其抑制剂与肿瘤多药耐药 被引量：3

Cyclooxygenase-2 and its inhibitor and multidrug resistance
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摘要 肿瘤多药耐药是目前化疗失败的最常见且最难解决的问题,环氧合酶-2参与肿瘤的发生发展,近年来一些研究表明,环氧合酶-2与肿瘤多药耐药密切相关,并且通过多条途径参与肿瘤多药耐药的发生,该文对环氧合酶-2及其抑制剂与肿瘤多药耐药的关系做一综述。 At present, muhidrug resistance （MDR） is the most common and difficult problem of failure of chemotherapy. Cyclooxygenase-2 （COX-2） participated in the development of tumor. Recently, the study showed that COX-2 was closely related to muhidrug resistance of turners and played an important role in the development of MDR through many paths. In this article the relationship between COX-2 and MDR is reviewed.
作者 张玲 陈同钰
机构地区 苏州大学附属第三医院病理科
出处 《国外医学（药学分册）》 2007年第3期177-180,共4页 Foreign Medical Sciences(Section of Pharmarcy)
关键词 环氧合酶-2 P糖蛋白 肿瘤多药耐药 cyclooxygenase-2 P-glycoprotein muhidrug resistance
分类号 R730.5 [医药卫生—肿瘤]
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参考文献3

二级参考文献17

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共引文献74

同被引文献27

  • 1郭贵龙,张筱骅,姚榛祥.环氧化酶-2抑制剂nimesulide对乳腺癌细胞株增生、凋亡的影响[J].肿瘤研究与临床,2005,17(1):6-9. 被引量：1
  • 2邓立春,姜藻.拓扑异构酶Ⅱ与肿瘤化疗[J].东南大学学报（医学版）,2005,24(4):284-287. 被引量：3
  • 3郭贵龙,李卓英,尤捷,张筱骅.Nimesulide对乳腺癌细胞株化疗敏感性的影响及机制研究[J].中华肿瘤防治杂志,2006,13(16):1214-1218. 被引量：1
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  • 10Shain KH,Dalton WS.Cell adhesion is a key determinant in de novo multidrug resistance (MDR):new targets for the prevention of acquired MDR[J].Mol Cancer Ther,2001,1(11):69-78.

引证文献3

二级引证文献10

国外医学（药学分册）
2007年 第3期

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