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天然化合物ACA的生物活性研究进展

Current research progress in the biological activity of ACA,a kind of natural chemical compound
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摘要 乙酰氧基胡椒酚乙酸酯(ACA)是一种从高良姜中提取的小分子天然化合物,具有抗肿瘤、杀菌、保护胃粘膜和抗艾滋病等生物学功能。大量的体内体外实验表明,ACA的抗肿瘤活性是广谱的,并且没有明显的副作用。ACA分子水平的可能作用方式在NF-κB信号途径的研究中得到了大致的确定。ACA在未来的临床和基础研究中将成为一种重要药物。 1 ＇-Acetoxychavicol acetate （ACA） is a kind of natural small molecular chemical compound, which is extracted from galangal. ACA possesses a lot of biological activities, such as anti-tumor, antibacterial, gastro-protective and anti-HIV activities. Many in vivo experiment results showed that ACA has no significant side effect in treatment. The mechanism research located ACA effect in the NF-kB signal pathway. ACA may play more and more important role in clinical and theoretical research in the future.
作者 卓心明 李博安
机构地区 厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室
出处 《国外医学（药学分册）》 2007年第3期181-186,共6页 Foreign Medical Sciences(Section of Pharmarcy)
关键词 ACA 肿瘤 NF—kB 艾滋病 ACA tumor NF-kB AIDS
分类号 R96 [医药卫生—药理学]
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国外医学（药学分册）
2007年 第3期

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