外伤性癫痫患者丙戊酸钠缓释片血药浓度监测

Serum concentration monitering of sodium valproate sustained-release tablet in traumatic epilepsy patients

目的：分析丙戊酸钠缓释片治疗外伤性癫痫患者的血药浓度，探讨其临床个体化用药。方法：采用荧光偏振免疫法测定患者丙戊酸钠的血药浓度，并分析其与疗效的关系。结果：血药浓度在50～100mg·L^-1的患者其癫痫症状控制较好，低于50mg·L^-1者癫痫症状控制较差，超过100mg·L^-1则容易出现副作用。结论：丙戊酸钠缓释片治疗外伤性癫痫惠者的血药浓度相对平稳，但仍有一定的个体差异，需进行必要的血药浓度监测，有利于临床安全合理用药。

Objective： To monitor the serum concentrations of sodium valproate for the clinical individual medi-cation. Methods： Fluorescence polarization immune analysis was applied to measure and evaluate the serum concentrations of sodium valproat in 120 traumatic epilepsy patients. Results： The serum concentrations of well-controlled patients are within 50～100mg·L^-1. If the blood concentration is lower than 50mg·L^-1, the symp-toms are not well controlled. In the contrary, if the blood concentration is out of 100mg·L^-1,it is easier to in-duce side effects. Conclusion： To monitor serum drug level is meaningful for clinical medication