摘要
目的:设计制备氨溴索口腔崩解片。方法:采用正交设计,根据口腔崩解片的特点选用不同辅料,考察各处方制备崩解片的溶出度和崩解时限。结果:最佳处方为:甘露醇10克,微晶纤维素30 g,羟丙纤维素8 g和碳酸氢钠1 g。结论:制备的氨溴索口腔崩解片崩解时限符合规定,口感良好,溶出速度明显优于普通片。
Objective： To design an formula of ambroxol hydrochloride orally disintegrating tablets. Method ： By using orthogonal design, different formula and active ingredients according to the characteristics of orally disinte-grating tablets were evaluated by the effect of disintegrating behavior and time limit observed. Results： The opti-mal formulation composed of mannitol 30g, cellulose microcrystallisate （MCC） 50 g, hydroxypropyl cellulose （L-HPC） 8 g and sodium bicarbonate 1 g. Conclusion： The disintegrating time of the tablets meet the qualifi- cation standard, and it have superior taste and dissolution rate compared with normal tablets.
出处
《药学与临床研究》
2007年第3期240-242,共3页
Pharmaceutical and Clinical Research
基金
江苏省卫生厅医学科技发展基金项目(编号:P200506)
关键词
盐酸氨溴索
口腔崩解片
崩解时限
溶出速度
研制
Ambroxol hydrochlorid
Orally disintegrating tablets
Disintegrating timing
Dissolution rate
