胸腺肽α1对ICU重度感染所致血小板减少症的作用

Effects of thymosin α_1 on thrombocytopenia resulting from severe infection in the patients from ICU

目的:观察胸腺肽α1治疗ICU重症感染患者及其对重症感染所致血小板减少症的影响。方法:20例ICU重症感染患者,分为A、B两组。两组患者均给予内科综合治疗措施;同时,B组患者还加用日达仙(胸腺肽α1,由美国赛生公司提供)治疗。结果:①治疗前,所有患者均存在血小板减少症,其WBC、NEUT均异常增高;②治疗过程中,B组患者WBC(P<0.05)及NEUT(P<0.01)有显著的恢复,而B组患者PLT也有明显的回升(P<0.05);③B组感染控制总有效率为90%,优于A组(其总有效率为70%),但没有统计学意义(P>0.05)。结论:日达仙综合内科保守治疗,有利于尽快纠正感染所致的血小板减少症,有利于ICU重症感染的控制。

Objective：To investigate the effect of Zadaxin （ thymosin α1 Tα1 ） on thrombocytopenia induced by severe infection in the patients from ICU. Methods：Twenty ICU patients with severe infection were assigned to 2 groups： Group A （ n = 10） treated with general therapy, Group B （ n = 10） treated with not only general but also Zadaxin therapy. The blood rou- tine was monitored before and during therapy, and the symptoms, signs as well as chest X-rays were also observed for all patients, and based on which, the curative effect would be evaluated for every patient. Results： （ 1 ） Before treatment, thrombocytopenia occurred to all patients, WBC and NEUT were in abnormally higher levels. （2） With the treatment, the levels of WBC （P 〈0.05） and NEUT （P 〈0.01 ） in the patients of Group B restored more markedly than those in the patients of Group A, and the level of PLT also restored more quickly in Group B than that in Group A （ P 〈 0.05 ）. （3） The total curative rate for infection was 90% in Group B higher than that in Group A with the total curative rate of 70% with no statistical significance between the two groups （ P 〉 0.05 ）. Conclusions. Zadaxin combined with other medicine therapy could promote the correction of the thrombocytopenia of the patients with severe infection, which would be beneficial to effectively control the severe infection of the patients from ICU.