非酒精性脂肪肝患者血清非高密度脂蛋白胆固醇水平检测分析

Detection of serum non-high-density lipoprotein cholesterol levels in patients with nonalcoholic fatty liver

目的了解非酒精性脂肪肝患者血清非高密度脂蛋白胆固醇（non-HDL-C）代谢水平,评价其临床应用价值。方法通过对单位体检者的影像学检查及肝功能、血糖、血脂等血清生化指标检测,并对其中非酒精性脂肪肝与体检健康者（对照组）进行比较。结果脂肪肝总检出率为9.15%,男性检出率12.50%,显著高于女性的5.99%（P〈0.05）;男性患者丙氨酸转氨酶（ALT）、间接胆红素（IBil）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（apoA1）、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、总胆固醇/高密度脂蛋白胆固醇（TC/HDL-C）等与对照组比较差异具有统计学意义（P〈0.05或P〈0.01）,女性患者天冬氨酸转氨酶（AST）、总胆红素（TBil）、直接胆红素（DBil）I、Bil、葡萄糖（Glu）、TC、TG、LDL-C、apoA1、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C与对照组比较差异具有统计学意义（P〈0.05或P〈0.01）;non-HDL-C与TC、LDL-C、TG、HDL-C、apoA1、apoB100、apoB100/apoA1、TC/HDL均显著相关（r=0.411~0.989,P〈0.01）。结论非酒精性脂肪肝普遍具有脂类代谢异常和肝脏受损特点,non-HDL-C的检测有助于全面了解非酒精性脂肪肝脂类代谢状况。

Objective To understand the clinical significance of serum non-high-density lipoprotein cholesterol （non-DHL-C） levels in the patients with nonalcoholic fatty liver. Methods The nonalcoholic fatty liver and the health persons（contrast group） physical examination were compared by image analysis and blood serum biochemical indicators about liver function, blood glucose（Glu） and blood fat. Results The detection rate of fatty liver was 9.15 %. The rate of male patients was 12.50 %, which was higher than that of female patients, 5.99 % （ P 〈0.05）. There were significant differences in the levels of alanine aminotransferase （ALT）, indirect bilirubin （IBiL）, triglyeride （TG）, high-density lipoprotein cholesterol（ HDL-C）, low-density lipoprotein cholesterol （ LDL-C）, apolipoprotein a （apoA1）, non-HDL-C, apoB100/apoA1, LDL-C/HDL-C, apoB100/HDL-C and TC/HDL-C between male patients and contrast group （ P 〈0.05 or P〈0.01）, also in the levels of aspartate aminotransferase （AST）, total bilirubin（TBiL）, direct bilirubin（DBiL）, IBiL, Glu, TC, TG, LDL-C, apoA1, non-HDL-C, apoB100/apoA1, LDL-C/HDL-C, apoB100/HDL-C and TC/HDL-C between female patients and contrast group （P〈0.05 or P 〈20.01）. Non-HDL-C was obviously associated with TC, LDL-C,TG,HDL-C,apoA1 ,apoB100 ,apoB100/apoA1 and TC/HDL-C （ r =0. 411-0. 989, P 〈0.01）. Conclusion The metabolism disorders exist in the patients with nonalcoholic fatty liver. Early detection of serum non-HDL-C levels may be helpful to know the metabolism condition of plasma lipids.