1Alcorta DA,Xiong Y,Phelps D,et al.Involvement of cyclin-dependent kinase lihibitor p16^INK4A in replicative senescence of normal human fibroblasts.Proc Natl Acad Sci USA,1996,93:13742
2Duan JM,Zhang ZY,Tong TJ.Senescence delay of human diploid fibroblast induced by anti-sense p16^INK4A expression.J Biol Chem,2001,276(51):48325
3Kamb A,Gruis NA,Weaver-Feldhaus J,et al.Acell cycle regulateor potentiallyinvolved in genesis of many tumor types.Science,1994,264(5157):436
4Zhang YP,Herman B.Apoptosis and successful aging.Mechanisms of ageing and development,2002,123:563
5Kim M,Katayose Y,Rojanala L,et al.Induction of apoptosis in p16^INK4A mutant cell lines by adenovirus-mediated overexpression of p16^INK4A protein.Cell Death and Differentiation,2000,7:706
6Ausserlechner MJ,Obexer P,Wiegers GJ,et al.The cell cycle inhibitor p16^INK4A sensitizes Lymphoblastic Leukemia cellsto apoptosis by physiologic glucocorticoid levels.J Bio Chem,2001,276:10984
7Fukuoka K,Nishio K,Fukumoto H,et al.Ectopic p16^INK4A Expression Enhances Cpt-11 induced Apoptosis through increased delay in S-phase progression in human Non-Small-Cell-Lung-Cancer cells.Int.J.Cancer,2000,86:197
8Katsuda K,Kataoka M,Uno F,et al.Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cell.Oncogene,2002,21:2108
9Calbo J,Marotta M,Casallo M,et al.Adenovirus-mediated WT-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer.Cancer Gene Therapy,2001,8:740
