血红素加氧酶与动脉粥样硬化

Heme oxygenase and atherosclerosis

目的:分析血红素加氧酶与动脉粥样硬化的关系和目前研究进展。资料来源:应用计算机检索Medline1995-01/2006-03相关文章,检索词“heme oxygenase,carbon monoxide,bilirubin,artherosclerosis”,并限定文章语言种类为“English”。同时用计算机检索CMB数据库1995-01/2006-03期间的相关文章,限定检索词为“血红素加氧酶、血红素氧合酶、一氧化碳、胆红素、动脉粥样硬化”。资料选择:选择血红素加氧酶与动脉粥样硬化相关的研究,并查找全文。纳入标准:①血红素加氧酶与动脉粥样硬化的相关研究。②胆红素、一氧化碳与动脉粥样硬化的关系。排除标准:①重复研究。②综述文章。资料提炼:共收集到有关血红素加氧酶和动脉粥样硬化方面文章214篇,排除重复或类似研究,然后总结血红素加氧酶与动脉粥样硬化的关系。资料综合:血红素加氧酶能将血红素催化降解成具有不同生物活性的铁、一氧化碳及胆红素。目前很多证据显示血红素加氧酶1及其代谢产物是氧化应激时体内一种重要的保护性蛋白。一方面限制血红素对机体的有害作用。另一方面其代谢产物胆红素具有抗氧化的作用。胆红素具有重要的抗氧化和抗血管损伤后内膜增殖的作用;CO有重要的抗炎、抗平滑肌细胞增殖作用。结论:血红素加氧酶可以明显的对抗动脉粥样硬化的发生和发展,并对血管介入术后再狭窄有重要的预防作用。

OBJECTIVE： To explore the correlation between heme oxygenase and atherosclerosis and recognize the latest research advancement. DATA SOURCES： A computer-based online search of Medline was undertaken for related articles published in English between January 1995 and March 2006 with the key words of ＂Heme oxygenase, carbon monoxide, bUirubin, atherosclerosis＂. Meanwhile, we searched the CMB database for related Chinese articles published between January 1995 and March 2006 with the same key words in Chinese. STUDY SELECTION： The literature about the association between heme oxygenase and atherosclerosis were selected, and then full-texts were searched. Inclusive criteria： （1）study on heme oxygenase and.atherosclerosis; （2）study about the relationship of bilirubin and carbon monoxide with atherosclerosis. Exclusive criteria： （1）repetitive research; （2）review articles. DATA EXTRACTION： 214 articles about heme oxygenase and atherosclerosis were collected. After excluding the repetitive or similar articles, we summarized the correlation between heme oxygenase and atherosclerosis. DATA SYNTHESIS： Heme oxygenase can breakdown heme into carbon monoxide, bilirubin, and free ferrous iron. Accumulating evidence has shown that inducible heme oxygenase and its metabolic products function as a kind of protective proteins in oxidative stress; it can inhibit the damage of ferroheme to body, and its metabolic products serve as antioxidant. Ferroheme has antioxidant and antiproliferative properties, and carbon monoxide plays antiproliferative and antiinflammatory roles. CONCLUSION： Heme oxygenase can inhibit the occurrence and development of atherosclerosis. In addition, it presents a preventive effect on the restenosis after percutaneous coronary intervention.