摘要
选择了Pmc作为胍基的保护基,应用Arndt-Eistert反应合成了N-Fmoc-L-β-高精氨酸。以Pmc保护胍基,反应中基本上消除了δ-内酰胺的生成,获得了产率较高的N-Fmoc-L--βArg(Pmc)-OH。
The N- Fmoe- L-β-homoArg （ Pme ）-OH was efficiently synthesized by using the Amdt-Eistert reaction with Pmc as the protecting group of guanidine. The formation of δ-lactam was basically eliminated during the synthetic reaction, leading to a total yield of N-Fmoc-L-β-Arg（Pmc）-OH reaching up to 85 %.
出处
《化学试剂》
CAS
CSCD
北大核心
2007年第2期113-114,116,共3页
Chemical Reagents
