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核因子相关因子2的调控与支气管哮喘 被引量：4

Regulation of Nrf2 and bronchial asthma
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摘要 γ-谷氨酰半胱氨酸合成酶（γ-GCS）是谷胱甘肽（GSH）合成的限速酶，其表达水平与活性对支气管哮喘（哮喘）有重要意义，核因子相关因子2（NF-E2 related factor2，Nrf2）能调控γ-GCS的表达。细胞外信号通过细胞内Keapl、Bachl、PERK等多种因素调节Nrf2的活性，而导致γ-GCS的活性改变，最终使得GSH含量改变，而参与哮喘发病过程。 The expression level and activity of gamma-glutamyl-cysteine synthetase（γ-GCS） ,which is the rate-limiting enzyme catalyzing GSH biosynthesis,plays a critical role in the bronchial asthma（asthma）, NF-E2 nelated factor2（Nrf2） can regulate the expression of γ-GCS. Extracellular signals can modulate the activity of Nrf2 via many intracellular factors such as Keapl,Bachl, PERK, resulting in alteration of γ-GCS activity and finally changing the level of GSH,thereby they take part in the asthma development.
作者 张秀峰 戴爱国 胡瑞成
机构地区 湖南省老年医院湖南老年医学研究所呼吸病研究室
出处 《国际呼吸杂志》 2007年第11期819-822,共4页 International Journal of Respiration
关键词 核因子相关因子-2 Γ-谷氨酰半胱氨酸合成酶 支气管哮喘 NF-E2 related factor2 γ-glutamyl-cysteine synthetase Bronchial asthma
分类号 R5 [医药卫生—内科学]
  • 相关文献

参考文献30

  • 1Fujisawa T. Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy, 2005,4 : 505-509.
  • 2Andreadis AA, Hazen SL, Comhair SA, et al. Oxidative and nitrosative events in asthma. Free Radic Biol Med, 2003,35 : 213- 225.
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二级参考文献6

共引文献15

同被引文献40

  • 1朱运福,戴爱国,胡瑞成.丝裂原活化蛋白激酶与核因子E_2相关因子调节γ谷氨酰半胱氨酸合成酶在豚鼠支气管哮喘中的作用[J].中华结核和呼吸杂志,2006,29(10):709-710. 被引量：2
  • 2朱运福,戴爱国,胡瑞成.支气管哮喘豚鼠肺组织中Nrf2对γ-GCS的作用[J].中国应用生理学杂志,2006,22(4):492-496. 被引量：11
  • 3Fujisawa T. Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy, 2005, 4:505-509.
  • 4Dhakshinamoorthy S, Jain AK, Bloom DA, et al. Bachl competes with Nrt2 leading to negative regulation of the antioxidant response element (ARE) -mediated NAD ( P ) H : quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J Biol Chem, 2005, 280 : 16891-16900.
  • 5Kobayashi M, Itoh K, Suzuki T, et al. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keapl system. Genes Cells, 2002, 7:807-820.
  • 6Yamasaki C, Tashiro S, Nishito Y, et al. Dynamic cytoplasmic anchoring of the transcription factor Bachl by intracellular hyaluronic acid binding protein IHABP. J Biochem (Tokyo), 2005, 137:287-296.
  • 7Igarashi K, Sun J. The heme-Bachl pathway in the regulation of oxidative stress response and erythroid differentiation. Antioxid Redox Signal, 2006, 8:107-118.
  • 8Shan Y, Lambrecht RW, Donohue SE, et al. Role of Bachl and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. Faseb J, 2006, 20:2651-2653.
  • 9Fujisawa T. Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy, 2005, 4: 505-509.
  • 10Dhakshinamoorthy S, Jain AK, Bloom DA, et al. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD (P)H: quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J Biol Chem, 2005, 280: 16891-16900.

引证文献4

二级引证文献9

国际呼吸杂志
2007年 第11期

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