鬼箭羽的化学成分研究

Chemical constituents from wing twigs of Euonymus alatus

目的 研究鬼箭羽Ewonymus alatus的化学成分。方法 利用硅胶、Sephadex LH-20、开放RP—C18柱色谱以及PTLC分离，经理化常数测定，结合1H—NMR13C—NMR、EI—MS鉴定结构。结果 从鬼箭羽95％乙醇提取物的氯仿萃取层中分得9个化合物，分别鉴定为表木栓醇（Ⅰ）、豆甾-4-烯-3-酮（I）、6p羟基-豆甾-4-烯-3-酮（Ⅲ）、β-谷甾醇（IV）、2，4-二羟基-3，6-二甲基苯甲酸甲酯（V）、2，4-二羟基-6-甲基苯甲酸甲酯（Ⅵ）、4-甲基-7-甲氧基异苯并呋喃酮（Ⅶ）、香草醛（Ⅷ）、正二十八烷醇（Ⅸ）。结论 化合物Ⅶ为-新天然产物，化合物Ⅴ～Ⅷ首次从该属植物中得到。

Objective To study the chemical constituents from the wing twigs of Euonyrnus alatus. Methods Compounds were isolated and purified repeatedly on silica gel, Sephadex LH-20, open RP-C18 column chromatographies and PTLC, and their chemical structures were elucidated by their physicochemical properties and spectral data, such as 1H-NMR, 13C-NMR, and EI-MS. Results Nine compounds were obtained and identified as ： epifriedelinol （ Ⅰ ）, stigmast-4-en-3-one （ Ⅱ ）, 6β-hydroxy-stigmast-4-en-3-one （ Ⅲ ）, β-sitosterol （ Ⅳ ）, methyl 2, 4-dihydroxy-3, 6-dimethyl benzoate （ Ⅴ）, methyl 2, 4-dihydroxy-6- methyl benzoate （ Ⅵ）, 7-methoxy-4-methylphthalide （Ⅶ）, vanillin （Ⅷ）, n-octacosanol （ Ⅸ ）. Conclusion Compound Ⅶ is first reported as a natural product. Compounds Ⅴ -Ⅷ are reported from plants of Euonyrnus L. for the first time.