黄芪多糖铬络合物的合成及其降血糖活性的初步研究

Preliminary Study on Preparation of Astragalus Polysaccharide-chromium Complex and Its Hypoglycemic Activities in Diabetic Animal Model

从黄芪药材中提取了黄芪多糖,制备黄芪多糖的铬络合物,并研究了黄芪多糖及其铬络合物对链脲佐菌素致高血糖小鼠模型的降糖作用。提取的黄芪多糖经过纯化后,在碱性条件下与三价铬离子络合,用IR、UV手段初步表征了络合物的形成。用链脲佐菌素致高血糖小鼠,药物分低、中、高三个剂量组给药,黄芪多糖铬络合物低、中、高三个剂量组与给药前相比都能显著降低高血糖小鼠的血糖(p<0.05),而黄芪多糖仅低剂量组与给药前相比有降糖效果(p<0.05)。因而黄芪多糖铬络合物具有比黄芪多糖更强的降糖效果,有一定的开发前景。

The polysaccharide was extracted from Astragalus to prepare the Astragalus polysaccharide-chromium complex and the effects of the polysaccharide and its chromium complex on blood levels of the diabetic mice induced by streptozotocin （STZ） were studied. The purified polysaccharides were coordinated with chromium （Ⅲ） in alkaline solution. The structure of the complex was expressed by the methods of IR and UV. The diabetic mice （i.g） were fed with the complex and polysaccharide respectively and recorded the weights and blood glucose levels of the diabetic mice. The prepared polysaccharides-chromium complex can significantly reduce the blood glucose of the diabetic mice in comparison with those before administration （p〈0.05）, while the Astragalus polysaccharide can reduce the blood glucose only by the low dose. The complex of polysaccharides-chromium has better effects on reducing blood glucose than those of polysaccharide alone.