摘要
目的:探讨穴位注射卡介菌多糖核酸(BCG-PSN)治疗尖锐湿疣(CA)的临床疗效及免疫学机制。方法:将200例患者随机分为4组,运用激光消除疣体后,治疗组(A组)用BCG-PSN穴位注射;对照1组(B组)用BCG-PSN肌肉注射;对照2组(C组)用干扰素肌肉注射;空白对照组(D组)未行其他治疗。治疗前及治疗6个月以后检测患者细胞免疫功能,并记录其复发情况。结果:A组治愈率为94.3%,B组为78.0%,C组为80.4%,D组为78.2%,A组与其他各组比较,治愈率均高于其他各组,差异有显著性意义(P<0.05);A组的CD4+的百分率升高,CD8+的百分率降低,CD4+/CD8+比值升高,自然杀伤细胞活性升高,复发率低,与各对照组比较,差异有统计学意义(P<0.05,P<0.01)。结论:BCG-PSN穴位注射治疗效果较好,可明显降低CA复发率,细胞免疫调节作用是该疗法防止CA复发的作用机制之一。
To probe into immunological mechanisms and clinical therapeutic effect of acupoint-injection of BCG polysaccharide nuclear acid (BCG-PSN) for treatment of condyloma acuminatum (CA). Methods Two hundred cases were randomly divided into 4 groups. After removed the CA by laser, the treatment group (group A) was treated with acupoint-injection of BCG-PSN, the control group I (group B) with intramuscular injection of BCG-PSN, the control group Ⅱ (group C) with intramuscular injection of interferon, and the blank control group (group D) with no treatment. The levels of cellular immune function were detected before treatment and after treatment of 6 months, and the cases of relapse were recorded. Results The cured rate of 94.3% in the group A was signifi- cantly higher than 78.0% in the group B, 80.4% in the group C and 78.2% in the group D, with significant differences (P〈0.05); in the group A, CD4^+ percent increased, CD8^+ percent decreased, CD4^+/CD8^+ ratio increased, and NK cell activity increased with a low relapse rate, and with significant differences as compared with the control groups (P〈0.05, P〈0.01). Conclusion Aeupoint-injeetion of BCG-PSN has a better therapeutic effect and it can obviously reduce the recurrence rate of CA. The cellular immunoregulatory action is one of the mechanisms of this therapy in preventing relapse of CA.
出处
《中国针灸》
CAS
CSCD
北大核心
2007年第6期407-411,共5页
Chinese Acupuncture & Moxibustion