摘要
目的:探讨针刺提高辅助生殖技术成功率的作用机制。方法:将孕鼠随机分为正常组、模型组及针刺组。模型组和针刺组均采用米非司酮造模,针刺组自妊娠第1天连续接受1w针刺治疗。观察各组大鼠妊娠率及平均着床胚泡数,比较其子宫、卵巢重量及单个胚泡大小、重量的差异;并用光镜观察各组大鼠子宫内膜及卵巢的形态结构差异。结果:针刺组妊娠率及平均着床胚泡数较模型组显著提高(P<0.01);模型组子宫、卵巢重量等均较正常组及针刺组轻,且子宫内膜发育不良;针刺组子宫内膜发育与正常组相似。结论:针刺可在一定程度上逆转米非司酮抗着床的作用,促进大鼠胚泡着床及胚泡发育。
To explore effects of acupuncture on embryo implantation and development in the rat with dysfunctional embryo implantation. Methods The pregnant rats were randomly divided into a control group, a model group and an acupuncture group. In the model group and the acupuncture group, the dysfunctional embryo implantation were developed by Mifepristone, and the acupuncture group were treated with acupuncture for one consecutive week from the first day of pregnancy. The pregnant rate, the average embryo implantation number, weight of the uterus, ovary and the size and weight of single embryo were compared among the 3 groups, and optical microscope was used for comparison of the morphological structures of the endometrium and ovary were compared among the 3 groups. Results In the acupuncture group, the pregnant rate, the average embryo implantation number were more significantly increased as compared with the model group （P^O. 01） ~ in the model group, the weight of the uterus and ovary were lighter than those in the control group and the acupuncture group, with poor development of the endometrium in the model group, but development of the endometrium in the acupuncture group was similar to that in the control group. Conclusion Acupuncture can reverse Mifepristone＇s anti-implantatlon effect to a certain extent, and promote implantation and development of embryo in the rat.
出处
《中国针灸》
CAS
CSCD
北大核心
2007年第6期439-442,共4页
Chinese Acupuncture & Moxibustion
基金
国家自然科学基金项目:90209009
