Survivin在脑胶质瘤组织中表达意义的研究

Experimental study on significance of Survivin expression in glioma

目的:探讨Survivin在脑胶质瘤组织中的表达及其与肿瘤异质性之间的联系。方法:应用免疫组织化学方法检测54例不同病理分级的脑胶质瘤组织Survivin蛋白的表达。结果:Survivin的表达程度随肿瘤级别升高而升高(P<0.01),而在正常脑组织中Survivin的表达为阴性。同时,不同级别胶质瘤Survivin蛋白表达的光密度值差异有统计学意义,组织级别越高,Survivin蛋白平均光密度值越大(P<0.01)。恶性胶质瘤周边浸润组织中也有Survivin表达,但低于瘤体中心。结论:胶质细胞瘤恶性程度与Survivin表达相关;Survivin的表达可作为胶质瘤恶性程度和浸润性的评估指标之一。

OBJECTIVE： To approach the relationship between the survivin expression and tumor heterogeneity. METHODS： Survivin expression in 54 cases of different pathologically classified glioma tissues was examined with the immunohistochemical method. RESULTS： The expression level of Survivin increased as the tumor grade increased （P〈.0.01）. However, in normal cerebral tissue, the expression of survivin was negative. At the same time, the different grade glioma had different optical densities of survivin protein, the higher the grade, the larger the survivin protein optical density （P〈0.01）. In the high grade glioma, peripheral infiltrating tissue had survivin expression, but was lower than tumor center. CONCLUSION： The malignancy of glioma is related to the expression of survivin, and survivin expression could be used as an evaluating standard for the tumor malignancy and infiltrating.